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B7VLI4 (ASTD_VIBSL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD
Gene names
Name:astD
Ordered Locus Names:VS_2859
OrganismVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32)) [Complete proteome] [HAMAP]
Taxonomic identifier575788 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
PRO_1000164408

Regions

Nucleotide binding220 – 2256NAD By similarity

Sites

Active site2431 By similarity
Active site2781 By similarity

Sequences

Sequence LengthMass (Da)Tools
B7VLI4 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: F8BA61A4A02AD0BE

FASTA48551,658
        10         20         30         40         50         60 
MTQWIAGQWV AGQGDAMTSV SPYNNEVVWQ GDSATPAQVE SAVAAARDAF LVWKKLSFAE 

        70         80         90        100        110        120 
REAIVLNFAE KVKENSEEIA QIIAKETGKP IWETRTEAGA MAGKIAISIR AYHERTGEAS 

       130        140        150        160        170        180 
REAAGNQIVL RHRPLGVMAV FGPYNFPGHL PNGHIVPALL SGNTVVFKPS EQTPWTGEFA 

       190        200        210        220        230        240 
MKLWQEAGLP AGVINLVQGA KETGIALADA KGLDGVLFTG SANTGHILHR QFAGQPGKML 

       250        260        270        280        290        300 
ALEMGGNNPM VISDQFGDAD ATVYTIIQSA FISAGQRCTC ARRLYVPVGE KGDQLLDKLV 

       310        320        330        340        350        360 
AATLKIRVDQ PFAEPAPFMG PQISEAAAKF ILDAQANLQS LGGVSLVEAK AGEAAFVSPG 

       370        380        390        400        410        420 
IIDATNIAEL PDEEYFGPLL QVVRYQSLEQ AVELANDTRF GLSAGLVSTD DSEWEYFVDH 

       430        440        450        460        470        480 
IRAGIVNRNR QLTGASGDAP FGGPGASGNL RPSAYYAADY CAYPMASMEG GETQLPATFS 


PGIEL

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References

[1]"Vibrio splendidus str. LGP32 complete genome."
Mazel D., Le Roux F.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LGP32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM954972 Genomic DNA. Translation: CAV20152.1.
RefSeqYP_002418397.1. NC_011753.2.

3D structure databases

ProteinModelPortalB7VLI4.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7VLI4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7162344.
GenomeReviewsGene locus VS_2859 in contig FM954972_GR.
KEGGvsp:VS_2859.
PATRIC20156256. VBIVibSpl48387_4070.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG752218.
OMADHIRAGI.
ProtClustDBPRK09457.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_VIBSL
AccessionPrimary (citable) accession number: B7VLI4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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