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B7VKF7

- SYL_VIBSL

UniProt

B7VKF7 - SYL_VIBSL

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Vibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVSPL575788:GH64-692-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:VS_0718
OrganismiVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Taxonomic identifieri575788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000009100: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 858858Leucine--tRNA ligasePRO_1000199233Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi575788.VS_0718.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi618 – 6225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7VKF7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYNPQEI EQKVQQHWDD SETFVVSEDP NKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVSRFQRLQG KNVMQPIGWD AFGLPAENAA VKNNTAPAPW
110 120 130 140 150
TYENIEYMKN QLKLLGFGYD WKREFATCTP EYYRWEQEFF TKLYEQGLVY
160 170 180 190 200
KKTSSVNWCP NDQTVLANEQ VEDGCCWRCD TPVEQKKIPQ WFIKITEYAQ
210 220 230 240 250
ELLDDLDNLE GWPEMVKTMQ RNWIGRSEGV ELSFAVNGEE APLEVYTTRP
260 270 280 290 300
DTLMGVSYVG IAAGHPLAEK ASKNNPELAA FVEECRNTKV AEAELATMEK
310 320 330 340 350
KGMDTGLTAI HPLNGRVVPV YVANFVLMDY GTGAVMAVPA HDQRDYEFAT
360 370 380 390 400
KYGIDIIPVI KPEDGSELDV SEAAYTEKGV LFDSGEFDGL AFQEAFDAIA
410 420 430 440 450
AKLEAEGKGK KTVNFRLRDW GVSRQRYWGA PIPMVTTEDG EVHPVPADQL
460 470 480 490 500
PVILPEDVVM DGVTSPIKAD KSWAETTFNG EPALRETDTF DTFMESSWYY
510 520 530 540 550
ARYCSPQADD ILDPEKANYW LPVDQYVGGI EHACMHLLYS RFFHKLLRDA
560 570 580 590 600
GYVTSDEPFK QLLCQGMVLA DAFYHENEKG TKEWIAPTDV TVERDGKGRI
610 620 630 640 650
EKAVDDQGRE VEHSGMIKMS KSKNNGIDPQ EMVDKYGADT VRLFMMFASP
660 670 680 690 700
ADMTLEWQES GVEGANRFLK RVWKLVHAHS SKGAAETVDA SALSGNQKAL
710 720 730 740 750
RRDIHKTIAK VTDDIGRRQT FNTAIAAIME LMNKLAKAPQ ESVQDRAILD
760 770 780 790 800
EALKAVVRML YPMTPHISYE MWIALGESNV DSATWPTFDE KALVEDEKTI
810 820 830 840 850
VVMINGKLRA KLTVAADATE EQVRELGLND ENAKKFLDGL TIRKVIFVPG

KLLNIVAN
Length:858
Mass (Da):96,921
Last modified:February 10, 2009 - v1
Checksum:iB3F6DA3F0E43E9A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM954972 Genomic DNA. Translation: CAV17713.1.
RefSeqiYP_002416360.1. NC_011753.2.

Genome annotation databases

EnsemblBacteriaiCAV17713; CAV17713; VS_0718.
GeneIDi7160337.
KEGGivsp:VS_0718.
PATRICi20152114. VBIVibSpl48387_2066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM954972 Genomic DNA. Translation: CAV17713.1 .
RefSeqi YP_002416360.1. NC_011753.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 575788.VS_0718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAV17713 ; CAV17713 ; VS_0718 .
GeneIDi 7160337.
KEGGi vsp:VS_0718.
PATRICi 20152114. VBIVibSpl48387_2066.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci VSPL575788:GH64-692-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Vibrio splendidus str. LGP32 complete genome."
    Mazel D., Le Roux F.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LGP32.

Entry informationi

Entry nameiSYL_VIBSL
AccessioniPrimary (citable) accession number: B7VKF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3