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Protein

NAD kinase

Gene

nadK

Organism
Vibrio tasmaniensis (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Proton acceptorUniRule annotation1
Binding sitei159NADUniRule annotation1
Binding sitei176NADUniRule annotation1
Binding sitei178NADUniRule annotation1
Binding sitei249NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 75NADUniRule annotation2
Nucleotide bindingi148 – 149NADUniRule annotation2
Nucleotide bindingi189 – 194NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:VS_0648
OrganismiVibrio tasmaniensis (strain LGP32) (Vibrio splendidus (strain Mel32))
Taxonomic identifieri575788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000009100 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001925291 – 294NAD kinaseAdd BLAST294

Interactioni

Protein-protein interaction databases

STRINGi575788.VS_0648

Structurei

3D structure databases

ProteinModelPortaliB7VJW6
SMRiB7VJW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

B7VJW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKPFEVIAI IGKPRDQQAI QTHRELYQWL STEGYQVFVD DRLATILDDI
60 70 80 90 100
PQEHFSSLIE LGKRADLAIV VGGDGNMLGA ARILSRFDIS VIGVNRGNLG
110 120 130 140 150
FLTDLNPENF QSALTDVLKG EFMEEERFLL ETEIHRHGQI KSHNAALNEA
160 170 180 190 200
VLHPGQVAHM IEFEVYIDDS FAFSQRSDGL IVSTPTGSTA YSLSGGGPIL
210 220 230 240 250
SSSLNAISLV PMFPHTLSSR PLVVDGKRRI KLIVSPDNRG TQEVSCDGQI
260 270 280 290
SLPVSPGDEI HIYQSPNVLK LIHPKDYNYY HVLRNKLGWS SKLF
Length:294
Mass (Da):32,677
Last modified:February 10, 2009 - v1
Checksum:iE3BDFABF9030EEBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM954972 Genomic DNA Translation: CAV17642.1
RefSeqiWP_009848328.1, NC_011753.2

Genome annotation databases

EnsemblBacteriaiCAV17642; CAV17642; VS_0648
GeneIDi7160267
KEGGivsp:VS_0648
PATRICifig|575788.5.peg.1998

Similar proteinsi

Entry informationi

Entry nameiNADK_VIBTL
AccessioniPrimary (citable) accession number: B7VJW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: June 20, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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