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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Vibrio tasmaniensis (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:VS_2502
OrganismiVibrio tasmaniensis (strain LGP32) (Vibrio splendidus (strain Mel32))
Taxonomic identifieri575788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000009100 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002010391 – 431Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiB7VJJ5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi575788.VS_2502

Structurei

3D structure databases

ProteinModelPortaliB7VJJ5
SMRiB7VJJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

B7VJJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSAELYEK AQQTIPGGVN SPVRAFNGVG GSPIFVERAD GPLIFDADGK
60 70 80 90 100
AYIDYVGSWG PMILGHNHVV IRDAVIAAAQ RGLSFGAPTE TEIKMAELVS
110 120 130 140 150
EMVPSMEQLR MVSSGTEATM SAIRLARGFT GRDKILKFEG CYHGHADSLL
160 170 180 190 200
VKAGSGALTL GQPSSPGVPA DFAKLTLTAT FNNLDSVREI FAANKGEIAC
210 220 230 240 250
IIVEPVAGNM NCIPPVEGFH EGLREICDQE GALLIFDEVM TGFRVAEGCA
260 270 280 290 300
QAYYNIKPDL TCLGKVIGGG MPVGAFGGRK DVMQYIAPTG PVYQAGTLSG
310 320 330 340 350
NPVAMAAGYA CLNLLREEGN EKRLASKTKQ LANGFKQLAD KHGIPMLVHQ
360 370 380 390 400
VGGMFGFFFT DQETVTCYED VTKCDVERFK RFFHLMLDHG VYLAPSAFEA
410 420 430
SFTSLAHGSK ELDATLEAAD RSLAIIAAES K
Length:431
Mass (Da):46,065
Last modified:February 10, 2009 - v1
Checksum:i0DB3B5160DF44BF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM954972 Genomic DNA Translation: CAV19659.1
RefSeqiWP_012604713.1, NC_011753.2

Genome annotation databases

EnsemblBacteriaiCAV19659; CAV19659; VS_2502
GeneIDi7162036
KEGGivsp:VS_2502

Similar proteinsi

Entry informationi

Entry nameiGSA_VIBTL
AccessioniPrimary (citable) accession number: B7VJJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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