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B7VJ78 (TYSY_VIBSL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase
Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:thyA
Ordered Locus Names:VS_0527
OrganismVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32)) [Complete proteome] [HAMAP]
Taxonomic identifier575788 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008

Subunit structure

Homodimer By similarity. HAMAP MF_00008

Subcellular location

Cytoplasm By similarity HAMAP MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Cellular componentCytoplasm
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthymidylate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Thymidylate synthase HAMAP MF_00008
PRO_1000197268

Sites

Active site1601 By similarity

Sequences

Sequence LengthMass (Da)Tools
B7VJ78 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 4B8E75CBD20C7AD6

FASTA28332,486
        10         20         30         40         50         60 
MKQYLDLCQR IVNDGTWIEN ERTGKRCLTV INADLEYDVG NNQFPLVTTR KSFWKAAVAE 

        70         80         90        100        110        120 
LLGYIRGYDN AEDFRKLGTK TWDANSNLNE AWLNNPYRKG EDDMGRVYGV QGRAWAKPDG 

       130        140        150        160        170        180 
GHIDQLKKIV DDLTNGIDDR GEILNFYNPG EFHMGCLRPC MYSHHFSLLG DTLYLNSTQR 

       190        200        210        220        230        240 
SCDVPLGLNF NMVQVYVFLA IMAQITGKKA GVAYHKLVNA HIYEDQLAPM RDIQLKREPL 

       250        260        270        280 
AGPTFHINPE IKSLEDLETW VTMDDFWVEG YECHEAIKYP FSV

« Hide

References

[1]"Vibrio splendidus str. LGP32 complete genome."
Mazel D., Le Roux F.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LGP32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM954972 Genomic DNA. Translation: CAV17532.1.
RefSeqYP_002416182.1. NC_011753.2.

3D structure databases

ProteinModelPortalB7VJ78.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7VJ78.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7160159.
GenomeReviewsGene locus VS_0527 in contig FM954972_GR.
KEGGvsp:VS_0527.
PATRIC20151754. VBIVibSpl48387_1891.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG588098.
OMAPIKYPFS.
ProtClustDBPRK01827.

Family and domain databases

HAMAPMF_00008. Thymidy_synth_bact.
[Tree]
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
Gene3DG3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
KOK00560.
PANTHERPTHR11549:SF2. Thymidylat_synth_C. 1 hit.
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. Thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_VIBSL
AccessionPrimary (citable) accession number: B7VJ78
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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