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B7VIW0

- UPPP_VIBSL

UniProt

B7VIW0 - UPPP_VIBSL

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, VS_0406
Organism
Vibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciVSPL575788:GH64-388-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:VS_0406
OrganismiVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Taxonomic identifieri575788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000009100: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed predictionAdd
BLAST
Transmembranei39 – 5921Helical; Reviewed predictionAdd
BLAST
Transmembranei83 – 10321Helical; Reviewed predictionAdd
BLAST
Transmembranei111 – 13121Helical; Reviewed predictionAdd
BLAST
Transmembranei144 – 16421Helical; Reviewed predictionAdd
BLAST
Transmembranei189 – 20921Helical; Reviewed predictionAdd
BLAST
Transmembranei218 – 23821Helical; Reviewed predictionAdd
BLAST
Transmembranei246 – 26621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Undecaprenyl-diphosphataseUniRule annotationPRO_1000148837Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi575788.VS_0406.

Structurei

3D structure databases

ProteinModelPortaliB7VIW0.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiMENIGWK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

B7VIW0-1 [UniParc]FASTAAdd to Basket

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MSYFEAFMLA LVQGFTEFLP ISSSAHLILP SAVLGWEDQG LAFDVAVHVG    50
TLAAVVIYFR KEVVSLLSAF FGSVFKGDRS KEAKLAWMII LATIPACIFG 100
LLMKDIVELY LRSAWVIATT TIIFGLLLWW VDKNSSLRDD EYQAGWKKAL 150
FIGLAQAMAI IPGTSRSGAT ITAALYLGFT REAAARFSFL MSIPIITLAG 200
GYLGLKLVTS GDPIHVGTLL TGIVVSFISA YICIHFFLKL ISRMGMTPFV 250
IYRLILGFGL FAFLMMQ 267
Length:267
Mass (Da):29,309
Last modified:February 10, 2009 - v1
Checksum:iE1195690BAE89804
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM954972 Genomic DNA. Translation: CAV17414.1.
RefSeqiYP_002416064.1. NC_011753.2.

Genome annotation databases

EnsemblBacteriaiCAV17414; CAV17414; VS_0406.
GeneIDi7160042.
KEGGivsp:VS_0406.
PATRICi20151514. VBIVibSpl48387_1771.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM954972 Genomic DNA. Translation: CAV17414.1 .
RefSeqi YP_002416064.1. NC_011753.2.

3D structure databases

ProteinModelPortali B7VIW0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 575788.VS_0406.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAV17414 ; CAV17414 ; VS_0406 .
GeneIDi 7160042.
KEGGi vsp:VS_0406.
PATRICi 20151514. VBIVibSpl48387_1771.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi MENIGWK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci VSPL575788:GH64-388-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Vibrio splendidus str. LGP32 complete genome."
    Mazel D., Le Roux F.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LGP32.

Entry informationi

Entry nameiUPPP_VIBSL
AccessioniPrimary (citable) accession number: B7VIW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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