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B7VI85

- CYSI_VIBSL

UniProt

B7VI85 - CYSI_VIBSL

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Protein
Sulfite reductase [NADPH] hemoprotein beta-component
Gene
cysI, VS_0300
Organism
Vibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate By similarity.UniRule annotation

Catalytic activityi

H2S + 3 NADP+ + 3 H2O = sulfite + 3 NADPH.UniRule annotation

Cofactori

Binds 1 siroheme per subunit By similarity.UniRule annotation
Binds 1 4Fe-4S cluster per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi438 – 4381Iron-sulfur (4Fe-4S) By similarity
Metal bindingi444 – 4441Iron-sulfur (4Fe-4S) By similarity
Metal bindingi484 – 4841Iron-sulfur (4Fe-4S) By similarity
Metal bindingi488 – 4881Iron (siroheme axial ligand) By similarity
Metal bindingi488 – 4881Iron-sulfur (4Fe-4S) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. NADP binding Source: InterPro
  3. heme binding Source: InterPro
  4. metal ion binding Source: UniProtKB-KW
  5. sulfite reductase (NADPH) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. cysteine biosynthetic process Source: UniProtKB-KW
  2. hydrogen sulfide biosynthetic process Source: UniProtKB-HAMAP
  3. sulfate assimilation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Cysteine biosynthesis

Keywords - Ligandi

4Fe-4S, Heme, Iron, Iron-sulfur, Metal-binding, NADP

Enzyme and pathway databases

BioCyciVSPL575788:GH64-289-MONOMER.
UniPathwayiUPA00140; UER00207.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfite reductase [NADPH] hemoprotein beta-component (EC:1.8.1.2)
Short name:
SiR-HP
Short name:
SiRHP
Gene namesi
Name:cysI
Ordered Locus Names:VS_0300
OrganismiVibrio splendidus (strain LGP32) (Vibrio splendidus (strain Mel32))
Taxonomic identifieri575788 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000009100: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. sulfite reductase complex (NADPH) Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575Sulfite reductase [NADPH] hemoprotein beta-componentUniRule annotation
PRO_0000388526Add
BLAST

Interactioni

Subunit structurei

Alpha(8)-beta8. The alpha component is a flavoprotein, the beta component is a hemoprotein By similarity.

Protein-protein interaction databases

STRINGi575788.VS_0300.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0155.
HOGENOMiHOG000218418.
KOiK00381.
OMAiELHQEAY.
OrthoDBiEOG6W9XFB.

Family and domain databases

Gene3Di3.90.480.10. 2 hits.
HAMAPiMF_01540. CysI.
InterProiIPR011786. CysI.
IPR005117. NiRdtase/SiRdtase_haem-b_fer.
IPR006067. NO2/SO3_Rdtase_4Fe4S_dom.
IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS.
[Graphical view]
PfamiPF01077. NIR_SIR. 2 hits.
PF03460. NIR_SIR_ferr. 2 hits.
[Graphical view]
PRINTSiPR00397. SIROHAEM.
SUPFAMiSSF55124. SSF55124. 2 hits.
TIGRFAMsiTIGR02041. CysI. 1 hit.
PROSITEiPS00365. NIR_SIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7VI85-1 [UniParc]FASTAAdd to Basket

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MSKQVIEQEV LGQVLGPLAD NERLKRESKN LRGTIEQDLE DRITGGFTAD    50
NFQLIRFHGM YQQDDRDIRN ERTKQKLEPL HNVMLRARMP GGIITPKQWL 100
AIDKFADEST SYGSIRLTTR QTFQFHGVLK PNIKLMHQTL NSIGIDSIAT 150
AGDVNRNVLC TTNPVESELH QEAYEWAKKI SEHLLPKTRA YAEIWLDGEK 200
LATTDEEPIL GSNYLPRKFK TTVVIPPQND VDVHANDLNF IAIAKDGKLV 250
GFNVLVGGGL AMTHGDTSTY ARKADDFGFV PLEKTLDVAA AVVTTQRDWG 300
NRSNRKNAKT KYTLDRVGID VFKAEVEKRA GVEFAESRPY EFTGRGDRIG 350
WAEGIDGKHH LALFIENGRL LDFPGKALKT GVAEIAKIHK GDFRMTANQN 400
LIVAGVLKSQ KAQIEKLARQ YGLMDDAVSE QRKNSMACVA FPTCPLAMAE 450
AERFLPEFVT DVEDILKKHG LPEEDNIILR ITGCPNGCGR AMLAELGLVG 500
KAPGRYNMHL GGNKAGTRIP KMYKENITSA QILEEIDSLV GRWATERTDN 550
EGFGDFTIRA GIIEEVIISK RDLHA 575
Length:575
Mass (Da):64,122
Last modified:February 10, 2009 - v1
Checksum:i60F39AC340FFFCEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM954972 Genomic DNA. Translation: CAV17322.1.
RefSeqiWP_012603121.1. NC_011753.2.
YP_002415974.1. NC_011753.2.

Genome annotation databases

EnsemblBacteriaiCAV17322; CAV17322; VS_0300.
GeneIDi7159951.
KEGGivsp:VS_0300.
PATRICi20151318. VBIVibSpl48387_1679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM954972 Genomic DNA. Translation: CAV17322.1 .
RefSeqi WP_012603121.1. NC_011753.2.
YP_002415974.1. NC_011753.2.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 575788.VS_0300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAV17322 ; CAV17322 ; VS_0300 .
GeneIDi 7159951.
KEGGi vsp:VS_0300.
PATRICi 20151318. VBIVibSpl48387_1679.

Phylogenomic databases

eggNOGi COG0155.
HOGENOMi HOG000218418.
KOi K00381.
OMAi ELHQEAY.
OrthoDBi EOG6W9XFB.

Enzyme and pathway databases

UniPathwayi UPA00140 ; UER00207 .
BioCyci VSPL575788:GH64-289-MONOMER.

Family and domain databases

Gene3Di 3.90.480.10. 2 hits.
HAMAPi MF_01540. CysI.
InterProi IPR011786. CysI.
IPR005117. NiRdtase/SiRdtase_haem-b_fer.
IPR006067. NO2/SO3_Rdtase_4Fe4S_dom.
IPR006066. NO2/SO3_Rdtase_FeS/sirohaem_BS.
[Graphical view ]
Pfami PF01077. NIR_SIR. 2 hits.
PF03460. NIR_SIR_ferr. 2 hits.
[Graphical view ]
PRINTSi PR00397. SIROHAEM.
SUPFAMi SSF55124. SSF55124. 2 hits.
TIGRFAMsi TIGR02041. CysI. 1 hit.
PROSITEi PS00365. NIR_SIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Vibrio splendidus str. LGP32 complete genome."
    Mazel D., Le Roux F.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LGP32.

Entry informationi

Entry nameiCYSI_VIBSL
AccessioniPrimary (citable) accession number: B7VI85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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