B7V9H3 (GLK_PSEA8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucokinase
EC=2.7.1.2

Alternative name(s):
Glucose kinase

Gene names

Name:	glk
Ordered Locus Names:	PLES_18751

Organism

Pseudomonas aeruginosa (strain LESB58) [Complete proteome] [HAMAP]

Taxonomic identifier

557722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa group › Pseudomonas aeruginosa

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the bacterial glucokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP glucokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Glucokinase HAMAP-Rule MF_00524		PRO_1000127714
Regions
	Nucleotide binding	16 – 21	6	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B7V9H3 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 321718790B5130D1	FASTA	331	34,606
	10 20 30 40 50 60 MNNDNKRSAG GLGLVGDIGG TNARFALWRG QRLESIEVLA CADYPRPELA VRDYLARIGE 70 80 90 100 110 120 SVANIDSVCL ACAGPVGAAD FRFTNNHWVI NRAAFREELG LDHLLLVNDF STMAWAASRL 130 140 150 160 170 180 GADELVQVRA GSAQADRARL IIGPGTGLGV GSLLPLGGGR WEVLPCEGGH VDLPVTSPRD 190 200 210 220 230 240 FALWQGLQAR YGHVSAERAL SGNGLLALYE ISCALDGVAV RASSAAEVGA LAMAGDAQAD 250 260 270 280 290 300 AVLEHFFLWL ARVAGNAVLT VGALGGVYIT GGIVPRFLER FIASGFAEAF ASRGKTSGAY 310 320 330 LQDVPVWVMT AEHPGLLGAG VALQQALDAE G

References

[1]

"Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa." Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C. Genome Res. 19:12-23(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LESB58.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM209186 Genomic DNA. Translation: CAW26603.1.
RefSeq	YP_002439479.1. NC_011770.1.
3D structure databases
ProteinModelPortal	B7V9H3.
SMR	B7V9H3. Positions 13-327.
ModBase	Search...
Protein-protein interaction databases
STRING	557722.PLES_18751.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAW26603; CAW26603; PLES_18751.
GeneID	7179867.
KEGG	pag:PLES_18751.
PATRIC	19813385. VBIPseAer113719_1948.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0837.
HOGENOM	HOG000274469.
KO	K00845.
OMA	EAVIRHY.
ProtClustDB	PRK00292.
Enzyme and pathway databases
BioCyc	PAER557722:GHJW-4902-MONOMER.
Family and domain databases
HAMAP	MF_00524. Glucokinase.
InterPro	IPR003836. Glucokinase. [Graphical view]
Pfam	PF02685. Glucokinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00749. glk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLK_PSEA8

Accession

Primary (citable) accession number: B7V9H3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program