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B7V776

- GCH4_PSEA8

UniProt

B7V776 - GCH4_PSEA8

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas aeruginosa (strain LESB58)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei149 – 1491May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPAER557722:GHJW-6031-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:PLES_59351
    OrganismiPseudomonas aeruginosa (strain LESB58)
    Taxonomic identifieri557722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000001527: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298GTP cyclohydrolase FolE2PRO_1000185155Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi557722.PLES_59351.

    Structurei

    3D structure databases

    ProteinModelPortaliB7V776.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiAGRTTIQ.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7V776-1 [UniParc]FASTAAdd to Basket

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    MNALTLPDIA RQTTTADLPL DWVGMQGIAL PVQIGGQRVA AEADAGVSLD    50
    DPQARGIHMS RLYLALAELE QGELDLSCLR AVLQRFLDSH AGLSRRAYLR 100
    LRLAPLLRRP ALVSPLSGWK RYPLVLDTRL EGDDFQAEVH LELTYSSTCP 150
    CSAALARQLI QERFDQDFAG QPLDHASVLA WLGSSAGIVA TPHSQRSSAH 200
    LRIGLAEDCI GLPLEELADL GESALGTAVQ TAVKRADEQA FALANGQNLM 250
    FCEDAVRRLH RALQGYPQAS RFSIRVVHAE SLHAHDAVAE SHWQRGAA 298
    Length:298
    Mass (Da):32,416
    Last modified:February 10, 2009 - v1
    Checksum:i56C9CF2B60280239
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM209186 Genomic DNA. Translation: CAW30689.1.
    RefSeqiYP_002443512.1. NC_011770.1.

    Genome annotation databases

    EnsemblBacteriaiCAW30689; CAW30689; PLES_59351.
    GeneIDi7179577.
    KEGGipag:PLES_59351.
    PATRICi19821835. VBIPseAer113719_6104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM209186 Genomic DNA. Translation: CAW30689.1 .
    RefSeqi YP_002443512.1. NC_011770.1.

    3D structure databases

    ProteinModelPortali B7V776.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557722.PLES_59351.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAW30689 ; CAW30689 ; PLES_59351 .
    GeneIDi 7179577.
    KEGGi pag:PLES_59351.
    PATRICi 19821835. VBIPseAer113719_6104.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi AGRTTIQ.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci PAER557722:GHJW-6031-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa."
      Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C.
      Genome Res. 19:12-23(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LESB58.

    Entry informationi

    Entry nameiGCH4_PSEA8
    AccessioniPrimary (citable) accession number: B7V776
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3