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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Pseudomonas aeruginosa (strain LESB58)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei234 – 2341UniRule annotation
Active sitei236 – 2361UniRule annotation
Active sitei241 – 2411UniRule annotation
Active sitei408 – 4081UniRule annotation
Active sitei410 – 4101UniRule annotation
Active sitei415 – 4151UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciPAER557722:GHJW-5886-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:PLES_57901
OrganismiPseudomonas aeruginosa (strain LESB58)
Taxonomic identifieri557722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalUniRule annotationAdd
BLAST
Transmembranei49 – 6921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cardiolipin synthase APRO_1000118592Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB7V5T6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini229 – 25628PLD phosphodiesterase 1UniRule annotationAdd
BLAST
Domaini403 – 43028PLD phosphodiesterase 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation
Contains 2 PLD phosphodiesterase domains.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000077402.
KOiK06131.
OMAiSANFRTH.
OrthoDBiEOG6Q2ST0.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA.
InterProiIPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7V5T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATGVDKDR PRAMTSTTYL GLLLVGIQVL GFVAAIHAVL TVRTAQGAIA
60 70 80 90 100
WATSLVFMPY LTLLPYLVFG RSRFDAYIEA RRQANREMHL AAAELDWRPW
110 120 130 140 150
VEEALAARQV SGYKGLKALV RMTRTPTLAN NRVRLLVNGE ASFEAMFKAI
160 170 180 190 200
SAARQVILVQ FFIVRDDALG QRLQQLLLER AANGVEVFFL YDAIGSHALP
210 220 230 240 250
HRYVERLRQG GVQMHGFSTG SGMLNRFQVN FRNHRKVVVV DGECGFVGGH
260 270 280 290 300
NVGVEYLGEK PPLAPWRDTH MELRGPAVAC LQESFAEDWY WATHSLPPLI
310 320 330 340 350
LPPQYDSEGA LCQVVASGPA DAQETCSLFF VEMINAAHER VWITSPYFVP
360 370 380 390 400
DEAVMAALRL AVLRGVDVRL LIPSRPDHRT VYAASSLYAL EAIRAGVKVF
410 420 430 440 450
RYQPGFLHQK VVLVDRDTAA VGSANLDNRS FRLNFEVMVV TVDEGFAGEV
460 470 480 490
EAMLEADFAE SLEFTPEDRR SVRRLQQLGM RVARLVSPIL
Length:490
Mass (Da):54,558
Last modified:February 10, 2009 - v1
Checksum:i9195298D93F38EEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM209186 Genomic DNA. Translation: CAW30544.1.

Genome annotation databases

EnsemblBacteriaiCAW30544; CAW30544; PLES_57901.
KEGGipag:PLES_57901.
PATRICi19821531. VBIPseAer113719_5952.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM209186 Genomic DNA. Translation: CAW30544.1.

3D structure databases

ProteinModelPortaliB7V5T6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAW30544; CAW30544; PLES_57901.
KEGGipag:PLES_57901.
PATRICi19821531. VBIPseAer113719_5952.

Phylogenomic databases

HOGENOMiHOG000077402.
KOiK06131.
OMAiSANFRTH.
OrthoDBiEOG6Q2ST0.

Enzyme and pathway databases

BioCyciPAER557722:GHJW-5886-MONOMER.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA.
InterProiIPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa."
    Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C.
    Genome Res. 19:12-23(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LESB58.

Entry informationi

Entry nameiCLSA_PSEA8
AccessioniPrimary (citable) accession number: B7V5T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: November 11, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.