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B7V4H6

- APAH_PSEA8

UniProt

B7V4H6 - APAH_PSEA8

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Protein
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
Gene
apaH, PLES_05871
Organism
Pseudomonas aeruginosa (strain LESB58)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

  1. bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPAER557722:GHJW-590-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC:3.6.1.41)
    Alternative name(s):
    Ap4A hydrolase
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
    Diadenosine tetraphosphatase
    Gene namesi
    Name:apaH
    Ordered Locus Names:PLES_05871
    OrganismiPseudomonas aeruginosa (strain LESB58)
    Taxonomic identifieri557722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000001527: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation
    PRO_1000118698Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi557722.PLES_05871.

    Structurei

    3D structure databases

    ProteinModelPortaliB7V4H6.
    SMRiB7V4H6. Positions 2-257.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Ap4A hydrolase family.

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000251871.
    KOiK01525.
    OMAiINAFTRM.
    OrthoDBiEOG66B3WP.

    Family and domain databases

    Gene3Di3.60.21.10. 2 hits.
    HAMAPiMF_00199. ApaH.
    InterProiIPR004617. ApaH.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
    SUPFAMiSSF56300. SSF56300. 1 hit.
    TIGRFAMsiTIGR00668. apaH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7V4H6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVYAVGDLQ GCLDPLKCLL ERVAFDPAKD RLWLVGDLVN RGPQSLETLR    50
    FLYAMRESVV SVLGNHDLHL LAVAHKSERL KKSDTLREIL EAPDREPLLD 100
    WLRRLPLLHY DEQRKVALVH AGIPPQWSLE KARLRAAEVE QALRDDQRLP 150
    LFLDGMYGNE PAKWDKKLHG IDRLRVITNY FTRMRFCTED GKLDLKSKEG 200
    LDTAPPGYAP WFSFPSRKTR GEKIIFGHWA ALEGHCDEPG LFALDTGCVW 250
    GARMTLLNVD SGERLSCDCA EQRAPARPAA TPA 283
    Length:283
    Mass (Da):32,019
    Last modified:February 10, 2009 - v1
    Checksum:iB7F21AE147168459
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM209186 Genomic DNA. Translation: CAW25314.1.
    RefSeqiYP_002438195.1. NC_011770.1.

    Genome annotation databases

    EnsemblBacteriaiCAW25314; CAW25314; PLES_05871.
    GeneIDi7175582.
    KEGGipag:PLES_05871.
    PATRICi19810684. VBIPseAer113719_0614.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM209186 Genomic DNA. Translation: CAW25314.1 .
    RefSeqi YP_002438195.1. NC_011770.1.

    3D structure databases

    ProteinModelPortali B7V4H6.
    SMRi B7V4H6. Positions 2-257.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 557722.PLES_05871.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAW25314 ; CAW25314 ; PLES_05871 .
    GeneIDi 7175582.
    KEGGi pag:PLES_05871.
    PATRICi 19810684. VBIPseAer113719_0614.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000251871.
    KOi K01525.
    OMAi INAFTRM.
    OrthoDBi EOG66B3WP.

    Enzyme and pathway databases

    BioCyci PAER557722:GHJW-590-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 2 hits.
    HAMAPi MF_00199. ApaH.
    InterProi IPR004617. ApaH.
    IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000903. B5n-ttraPtase_sm. 1 hit.
    SUPFAMi SSF56300. SSF56300. 1 hit.
    TIGRFAMsi TIGR00668. apaH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa."
      Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C.
      Genome Res. 19:12-23(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LESB58.

    Entry informationi

    Entry nameiAPAH_PSEA8
    AccessioniPrimary (citable) accession number: B7V4H6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: June 11, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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