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B7V4H6 (APAH_PSEA8) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

EC=3.6.1.41
Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase
Gene names
Name:apaH
Ordered Locus Names:PLES_05871
OrganismPseudomonas aeruginosa (strain LESB58) [Complete proteome] [HAMAP]
Taxonomic identifier557722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP-Rule MF_00199

Catalytic activity

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP-Rule MF_00199

Sequence similarities

Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionbis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP-Rule MF_00199
PRO_1000118698

Sequences

Sequence LengthMass (Da)Tools
B7V4H6 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: B7F21AE147168459

FASTA28332,019
        10         20         30         40         50         60 
MAVYAVGDLQ GCLDPLKCLL ERVAFDPAKD RLWLVGDLVN RGPQSLETLR FLYAMRESVV 

        70         80         90        100        110        120 
SVLGNHDLHL LAVAHKSERL KKSDTLREIL EAPDREPLLD WLRRLPLLHY DEQRKVALVH 

       130        140        150        160        170        180 
AGIPPQWSLE KARLRAAEVE QALRDDQRLP LFLDGMYGNE PAKWDKKLHG IDRLRVITNY 

       190        200        210        220        230        240 
FTRMRFCTED GKLDLKSKEG LDTAPPGYAP WFSFPSRKTR GEKIIFGHWA ALEGHCDEPG 

       250        260        270        280 
LFALDTGCVW GARMTLLNVD SGERLSCDCA EQRAPARPAA TPA 

« Hide

References

[1]"Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa."
Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C.
Genome Res. 19:12-23(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LESB58.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM209186 Genomic DNA. Translation: CAW25314.1.
RefSeqYP_002438195.1. NC_011770.1.

3D structure databases

ProteinModelPortalB7V4H6.
SMRB7V4H6. Positions 2-257.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING557722.PLES_05871.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAW25314; CAW25314; PLES_05871.
GeneID7175582.
KEGGpag:PLES_05871.
PATRIC19810684. VBIPseAer113719_0614.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000251871.
KOK01525.
OMAINAFTRM.
OrthoDBEOG66B3WP.

Enzyme and pathway databases

BioCycPAER557722:GHJW-590-MONOMER.

Family and domain databases

Gene3D3.60.21.10. 2 hits.
HAMAPMF_00199. ApaH.
InterProIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMSSF56300. SSF56300. 1 hit.
TIGRFAMsTIGR00668. apaH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAPAH_PSEA8
AccessionPrimary (citable) accession number: B7V4H6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families