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B7V3T9

- PCKA_PSEA8

UniProt

B7V3T9 - PCKA_PSEA8

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Protein
Phosphoenolpyruvate carboxykinase [ATP]
Gene
pckA, PLES_55861
Organism
Pseudomonas aeruginosa (strain LESB58)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA By similarity.UniRule annotation

Catalytic activityi

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451Substrate By similarity
Binding sitei179 – 1791Substrate By similarity
Metal bindingi185 – 1851Manganese By similarity
Binding sitei185 – 1851ATP By similarity
Binding sitei185 – 1851Substrate By similarity
Metal bindingi204 – 2041Manganese; via tele nitrogen By similarity
Binding sitei204 – 2041ATP By similarity
Metal bindingi241 – 2411Manganese By similarity
Binding sitei269 – 2691ATP By similarity
Binding sitei305 – 3051ATP By similarity
Binding sitei305 – 3051Substrate By similarity
Binding sitei431 – 4311ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi220 – 2289ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. phosphoenolpyruvate carboxykinase (ATP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAER557722:GHJW-5677-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [ATP] (EC:4.1.1.49)
Short name:
PCK
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckA
Ordered Locus Names:PLES_55861
OrganismiPseudomonas aeruginosa (strain LESB58)
Taxonomic identifieri557722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001527: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Phosphoenolpyruvate carboxykinase [ATP]UniRule annotation
PRO_1000125081Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi557722.PLES_55861.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1866.
HOGENOMiHOG000271471.
KOiK01610.
OMAiGADPEHY.
OrthoDBiEOG6DG2RK.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
TIGRFAMsiTIGR00224. pckA. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7V3T9-1 [UniParc]FASTAAdd to Basket

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MTQANNAVYT DISAAQLVEE AIRRGEGELA ANGSLVVRTG HRTGRSPVDR    50
FIVEEPSTKD AIAWGNINRP FPADKFDALW ARVEAFNNAQ DHFISHVHVG 100
SAEAYYLPVK MTTATAWQNL FGRCLFIEPE QYNPAGKDEW QVLNVANFEC 150
VPERDGTNSD GCVILNFAQK KVLIAGMRYA GEMKKAMFSV QNFLLPERDV 200
LPMHCAANIG EAGDVTLFFG LSGTGKTTLS ADESRYLIGD DEHGWGEGVV 250
FNVEGGCYAK CIDLSEKNEP VIWKAIKFGA VLENVVLDEE RVPNYADDSL 300
TQNSRAAYPL EHVEKRSEKN LGGEPNAVIF LTCDLTGVLP PVSILNNEQA 350
AYHFLSGYTA LVGSTEMGSG GGIKSTFSTC FGAPFFPRPA GVYAELLIKR 400
IKAFGSKVYL VNTGWTGGGY GVGKRFNIPT TRGVIAAIQS GALIGAETEH 450
LDIINLDVPK AVPGVETNLL NPRNTWADKA AYDEAAKGLA KQFIENFKKF 500
EVSDAIKAAG PQL 513
Length:513
Mass (Da):55,732
Last modified:February 10, 2009 - v1
Checksum:iBFE7F109710B124C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM209186 Genomic DNA. Translation: CAW30340.1.
RefSeqiYP_002443164.1. NC_011770.1.

Genome annotation databases

EnsemblBacteriaiCAW30340; CAW30340; PLES_55861.
GeneIDi7179271.
KEGGipag:PLES_55861.
PATRICi19821099. VBIPseAer113719_5741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM209186 Genomic DNA. Translation: CAW30340.1 .
RefSeqi YP_002443164.1. NC_011770.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557722.PLES_55861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAW30340 ; CAW30340 ; PLES_55861 .
GeneIDi 7179271.
KEGGi pag:PLES_55861.
PATRICi 19821099. VBIPseAer113719_5741.

Phylogenomic databases

eggNOGi COG1866.
HOGENOMi HOG000271471.
KOi K01610.
OMAi GADPEHY.
OrthoDBi EOG6DG2RK.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci PAER557722:GHJW-5677-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00453. PEPCK_ATP.
InterProi IPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view ]
Pfami PF01293. PEPCK_ATP. 1 hit.
[Graphical view ]
PIRSFi PIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
TIGRFAMsi TIGR00224. pckA. 1 hit.
PROSITEi PS00532. PEPCK_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa."
    Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C.
    Genome Res. 19:12-23(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LESB58.

Entry informationi

Entry nameiPCKA_PSEA8
AccessioniPrimary (citable) accession number: B7V3T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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