B7V2F7 (B7V2F7_PSEA8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase 2 HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE2 HAMAP MF_00222
Ordered Locus Names:	PLES_02411

Organism

Pseudomonas aeruginosa (strain LESB58) [Complete proteome] [HAMAP]

Taxonomic identifier

557722 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222 SAAS SAAS022893
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	135 – 139	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	75	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	B7V2F7 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 1B5CFF77FC7F473A	FASTA	284	29,691
	10 20 30 40 50 60 MSAPRSVLAG LIGAGIQASR TPALHEREGD AQGIRYLYRL IDLDPLGKSA DDLEFLLAAA 70 80 90 100 110 120 SDLGFTGLNV TFPCKQAIIP LLDDLSAEAR GIGAVNTVVL RDGRRIGHNT DCLGFAEGFR 130 140 150 160 170 180 RGLADAPRQR VVQMGAGGAG AAVAHALLAE GVERLVLFDV DPARAQALAD NLNQHFGAPR 190 200 210 220 230 240 ALAGSDLAGA LGDAQGLVNT TPVGMAKLPG MPVPAELLRA DLWVAEVIYF PLETELLRQA 250 260 270 280 RALGCRTLDG GTMAVFQAVK AFELFSGVTA DAARMQAHFA SLGD

References

[1]

"Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa." Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C. Genome Res. 19:12-23(2009) [PubMed: 19047519] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM209186 Genomic DNA. Translation: CAW24968.1.
RefSeq	YP_002437849.1. NC_011770.1.
3D structure databases
ProteinModelPortal	B7V2F7.
SMR	B7V2F7. Positions 6-282.
ModBase	Search...
Protein-protein interaction databases
STRING	B7V2F7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7175342.
GenomeReviews	Gene locus PLES_02411 in contig FM209186_GR.
KEGG	pag:PLES_02411.
PATRIC	19809948. VBIPseAer113719_0248.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	HEHEGDA.
ProtClustDB	PRK12549.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B7V2F7_PSEA8

Accession

Primary (citable) accession number: B7V2F7

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)