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B7UZU5 (STHA_PSEA8) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Soluble pyridine nucleotide transhydrogenase
Short name=STH
EC=1.6.1.1
Alternative name(s):
NAD(P)(+) transhydrogenase [B-specific]
Gene names
Name:sthA
Ordered Locus Names:PLES_20711
OrganismPseudomonas aeruginosa (strain LESB58) [Complete proteome] [HAMAP]
Taxonomic identifier557722 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity. HAMAP MF_00247

Catalytic activity

NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247

Cofactor

Binds 1 FAD per subunit By similarity. HAMAP MF_00247

Subcellular location

Cytoplasm By similarity HAMAP MF_00247.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
NAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD(P)+ transhydrogenase (B-specific) activity

Inferred from electronic annotation. Source: EC

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 464464Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247
PRO_1000193458

Regions

Nucleotide binding35 – 4410FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B7UZU5 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 886CEAB5479997A9

FASTA46451,161
        10         20         30         40         50         60 
MAVYNYDVVI LGTGPAGEGA AMNASKYGRK LAVVDSRRVV GGNCTHLGTI PSKALRHSVK 

        70         80         90        100        110        120 
QIIEFNTNPM FRQIGEPRWF SFPDVLKSAD RVISKQVASR TGYYARNRID MFTGTASFVD 

       130        140        150        160        170        180 
ERTVEVVTPS GAVERLVADQ FVIATGSRPY RPSDINFNHP RVYDSDTILS LSHTPRRLII 

       190        200        210        220        230        240 
YGAGVIGCEY ASIFSGLGVL VDLIDTRDQL LSFLDDEISD ALSYHLRNNN VLIRHNEEYE 

       250        260        270        280        290        300 
RVEGLDNGVI LHLKSGKKIK ADALLWCNGR TGNTDKLGLE NVGIKVNSRG QIEVDENYRT 

       310        320        330        340        350        360 
SVSNIFAAGD VIGWPSLASA AYDQGRSAAG NIVESDSWRF VNDVPTGIYT IPEISSIGKN 

       370        380        390        400        410        420 
ESELTAAKIP YEVGKAFFKG MARAQISNEP VGMLKILFHR ETLEILGVHC FGDQASEIVH 

       430        440        450        460 
IGQAIMNQPG ELNTLKYFVN TTFNYPTMAE AYRVAAFDGL NRLF

« Hide

References

[1]"Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa."
Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C.
Genome Res. 19:12-23(2009) [PubMed: 19047519] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LESB58.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM209186 Genomic DNA. Translation: CAW26798.1.
RefSeqYP_002439674.1. NC_011770.1.

3D structure databases

ProteinModelPortalB7UZU5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7UZU5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7176650.
GenomeReviewsGene locus PLES_20711 in contig FM209186_GR.
KEGGpag:PLES_20711.
PATRIC19813793. VBIPseAer113719_2143.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG515043.
OMAGEGNTIE.
ProtClustDBPRK05249.

Family and domain databases

HAMAPMF_00247. SthA.
[Tree]
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
IPR022962. STH.
[Graphical view]
Gene3DG3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
KOK00322.
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSTHA_PSEA8
AccessionPrimary (citable) accession number: B7UZU5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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