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Protein

LexA repressor

Gene

lexA

Organism
Pseudomonas aeruginosa (strain LESB58)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

Catalytic activityi

Hydrolysis of Ala-|-Gly bond in repressor LexA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei125For autocatalytic cleavage activity1
Active sitei162For autocatalytic cleavage activity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 48H-T-H motifAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase, Repressor
Biological processDNA damage, DNA repair, DNA replication, SOS response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
LexA repressor (EC:3.4.21.88)
Gene namesi
Name:lexA
Ordered Locus Names:PLES_20551
OrganismiPseudomonas aeruginosa (strain LESB58)
Taxonomic identifieri557722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001927741 – 204LexA repressorAdd BLAST204

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei90 – 91Cleavage; by autolysis2

Keywords - PTMi

Autocatalytic cleavage

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliB7UYS3.
SMRiB7UYS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S24 family.

Phylogenomic databases

HOGENOMiHOG000232167.
KOiK01356.
OMAiRQMMQAM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00015. LexA. 1 hit.
InterProiView protein in InterPro
IPR006200. LexA.
IPR036286. LexA/Signal_pep-like_sf.
IPR006199. LexA_DNA-bd_dom.
IPR006197. Peptidase_S24_LexA.
IPR015927. Peptidase_S24_S26A/B/C.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
PRINTSiPR00726. LEXASERPTASE.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR00498. lexA. 1 hit.

Sequencei

Sequence statusi: Complete.

B7UYS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKLTPRQAE ILSFIKRCLE DHGFPPTRAE IAQELGFKSP NAAEEHLKAL
60 70 80 90 100
ARKGAIEMTP GASRGIRIPG FEPHAANDDE GLPVIGRVAA GAPILAEQNI
110 120 130 140 150
EESCRINPAF FNPRADYLLR VRGMSMKDIG ILDGDLLAVH VTREARNGQV
160 170 180 190 200
VVARIGEEVT VKRFKREGSK VWLLAENPEF APIEVDLKEQ ELIIEGLSVG

VIRR
Length:204
Mass (Da):22,506
Last modified:February 10, 2009 - v1
Checksum:i665DF87928D48E94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM209186 Genomic DNA. Translation: CAW26782.1.
RefSeqiWP_003091196.1. NC_011770.1.

Genome annotation databases

EnsemblBacteriaiCAW26782; CAW26782; PLES_20551.
KEGGipag:PLES_20551.

Similar proteinsi

Entry informationi

Entry nameiLEXA_PSEA8
AccessioniPrimary (citable) accession number: B7UYS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: October 25, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families