true2009-07-282024-03-2785FADB_PSEA8Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa.Winstanley C.Langille M.G.I.Fothergill J.L.Kukavica-Ibrulj I.Paradis-Bleau C.Sanschagrin F.Thomson N.R.Winsor G.L.Quail M.A.Lennard N.Bignell A.Clarke L.Seeger K.Saunders D.Harris D.Parkhill J.Hancock R.E.W.Brinkman F.S.L.Levesque R.C.doi:10.1101/gr.086082.1082009Genome Res.1912-23NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]LESB58crotonase-likeNAD(P)-binding Rossmann-like DomainFadB3-OHacyl-CoA_DH_CS3-OHacyl-CoA_DH_NAD-bd3HC_DH_C6-PGluconate_DH-like_C_sfClpP/crotonase-like_dom_sfEnoyl-CoA_hyd/isom_CSEnoyl-CoA_hydra/isoFadBNAD(P)-bd_dom_sfFadBFATTY ACID OXIDATION COMPLEX SUBUNIT ALPHATRIFUNCTIONAL ENZYME SUBUNIT ALPHA3HCDH3HCDH_NECH_16-phosphogluconate dehydrogenase C-terminal domain-likeClpP/crotonaseNAD(P)-binding Rossmann-fold domains3HCDHENOYL_COA_HYDRATASEFatty acid oxidation complex subunit alphaEnoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase4.2.1.175.1.2.35.3.3.83-hydroxyacyl-CoA dehydrogenase1.1.1.35fadBPLES_20481Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Fatty acid oxidation complex subunit alpha769541715Enoyl-CoA hydratase/isomerase1903-hydroxyacyl-CoA dehydrogenase312For 3-hydroxyacyl-CoA dehydrogenase activity451297325344401403408430454501660Important for catalytic activity120Important for catalytic activity140substrate2009-02-1017695455fe83262017e2e23c660dbe95aef357MIYQGKAITVKPLEGGIVELNFDLKGESVNKFNRLTLSELRAAVDAIKADASVKGVIVTSGKDVFIVGADITEFVDNFQLPDEELMAGNLEANKIFSDFEDLDVPTVAAINGIALGGGLEMCLAADFRVMSATAKVGLPEVKLGIYPGFGGTVRLPRLIGCDNAVEWIASGKENKAEDALKVGAVDAVVAPEQLQAAALDLAKRAVAGELDHKARRQPKLEKLKLNAIEQMMAFETAKGFVAGQAGPNYPAPVEAIKSIQKAANFGRDKALEVEAAGFVKLAKTSVAQSLIGLFLNDQELKKKAKKYDEVAKDVKLAAVLGAGIMGGGIAYQSALKGTPILMKDIREEGIQMGLNEAAKLLGKRVEKGRLTPAKMAEALNGIRPTMSYGDFGNVDIVVEAVVENPKVKQAVLAEVEGAVKEDAIIASNTSTISISLLAQALKRPENFCGMHFFNPVHMMPLVEVIRGEKTGETAIATTVAYAKKMGKSPIVVNDCPGFLVNRVLFPYFGGFAKLLSFGVDFVRIDKVMEKFGWPMGPAYLSDVVGIDTGHHGRDVMAEGFPDRMAVEGKTAVDVMYEANRLGQKNGKGFYAYETDKRGKPKKVTDPQAYEVLKPIVVEQREVTDEDIVNFMMIPLCLETVRCLEDGIVETAAEADMGLIYGIGFPPFRGGALRYIDSIGVAEFVALADKYAELGALYHPTAKLREMAKNGQKFFGtrue