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B7UV83

- GLSA_PSEA8

UniProt

B7UV83 - GLSA_PSEA8

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Protein

Glutaminase

Gene
glsA, PLES_36891
Organism
Pseudomonas aeruginosa (strain LESB58)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611Substrate By similarity
Binding sitei111 – 1111Substrate By similarity
Binding sitei155 – 1551Substrate By similarity
Binding sitei162 – 1621Substrate By similarity
Binding sitei186 – 1861Substrate By similarity
Binding sitei238 – 2381Substrate By similarity
Binding sitei256 – 2561Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPAER557722:GHJW-3738-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:PLES_36891
OrganismiPseudomonas aeruginosa (strain LESB58)
Taxonomic identifieri557722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001527: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302GlutaminaseUniRule annotationPRO_1000119535Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi557722.PLES_36891.

Structurei

3D structure databases

ProteinModelPortaliB7UV83.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiMSIAVWS.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

B7UV83-1 [UniParc]FASTAAdd to Basket

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MQQLLNEILD EVRPLIGRGK VADYIPALAG VEPNQLGIAV YSRDGELFHA    50
GDALRPFSIQ SISKVFSLVQ AIQHSGEDIW QRLGHEPSGQ PFNSLVQLEF 100
ERGKPRNPFI NAGALVICDI NQSRFAAPAQ SMRDFVRRLC GNPEVVSDSV 150
VARSEYQHRS RNAAAAYLMK SFGNFHNDVE AVLLSYFHHC ALRMSCVDLA 200
RAFCFLADKG FCKHSGEQVL NERQTKQVNA IMATSGLYDE AGNFAYRVGL 250
PGKSGVGGGI IAVVPGRFTV CVWSPELNAA GNSLAGIAAL EKLSERIGWS 300
IF 302
Length:302
Mass (Da):33,012
Last modified:February 10, 2009 - v1
Checksum:iB8AE7C2389E3B2E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM209186 Genomic DNA. Translation: CAW28416.1.
RefSeqiYP_002441274.1. NC_011770.1.

Genome annotation databases

EnsemblBacteriaiCAW28416; CAW28416; PLES_36891.
GeneIDi7177909.
KEGGipag:PLES_36891.
PATRICi19817155. VBIPseAer113719_3803.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM209186 Genomic DNA. Translation: CAW28416.1 .
RefSeqi YP_002441274.1. NC_011770.1.

3D structure databases

ProteinModelPortali B7UV83.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557722.PLES_36891.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAW28416 ; CAW28416 ; PLES_36891 .
GeneIDi 7177909.
KEGGi pag:PLES_36891.
PATRICi 19817155. VBIPseAer113719_3803.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi MSIAVWS.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci PAER557722:GHJW-3738-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa."
    Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C.
    Genome Res. 19:12-23(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LESB58.

Entry informationi

Entry nameiGLSA_PSEA8
AccessioniPrimary (citable) accession number: B7UV83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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