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B7UV17

- B7UV17_PSEA8

UniProt

B7UV17 - B7UV17_PSEA8

Protein
Submitted name:

Isocitrate dehydrogenase

Gene

idh

Organism
Pseudomonas aeruginosa (strain LESB58)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei146 – 1461SubstrateUniRule annotation
    Sitei255 – 2551Critical for catalysisUniRule annotation
    Metal bindingi350 – 3501Magnesium or manganese
    Sitei420 – 4201Critical for catalysisUniRule annotation
    Binding sitei547 – 5471SubstrateUniRule annotation
    Metal bindingi548 – 5481Magnesium or manganese
    Metal bindingi552 – 5521Magnesium or manganese

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciPAER557722:GHJW-2517-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenaseImported
    Gene namesi
    Name:idhImported
    Ordered Locus Names:PLES_24811Imported
    OrganismiPseudomonas aeruginosa (strain LESB58)Imported
    Taxonomic identifieri557722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000001527: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi557722.PLES_24811.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 1408Substrate bindingUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiSIVKLMQ.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7UV17-1 [UniParc]FASTAAdd to Basket

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    MSIRSKITYT FTDEAPALAT YSLLPIVKAF AASAGIDVET SDISLAGRIL    50
    ANFADRLEAD QRIEDDLARL AALATSPDAN IIKLPNISAS VPQLKGAIAE 100
    LQGLGYKVPD FPEDPQTDEE KEVRARYAKI LGSAVNPVLR EGNSDRRAPA 150
    AVKAYARKHP HSMGKWSMAS RSHADYMRGG DFFSSEQSIT MAKAGDVRIE 200
    FVGKDGKVEV KKQLSLQEGE VLDSMFMSCG KLRDFFEKTL QDCKETGVMW 250
    SLHVKATMMK ISHPIVFGHA VSVYYKDVFD KWGQLFEELG VNPNNGISSV 300
    YDKIKSLPAS QQEEILHDIH EVYSHRPEMA MVDSVKGITN LHIPSDVIVD 350
    ASMPAMIRNS GQMWGKDGKQ KDTKAVMPES TYARIYQEMI NFCKTNGAFD 400
    PTTMGSVPNV GLMAQKAEEY GSHDKTFEMT ADGTMRVVLA DGSVLMQHDV 450
    ETGDIWRACQ TKDAPIRDWV KLAVTRARQS DTPAIFWLDP ERAHDRELRK 500
    KVELYLKDHD LTGLDISIMG YNEAIRVSME RLIRGKDTIS VTGNVLRDYL 550
    TDLFPIMELG TSAKMLSIVP LMAGGGMYET GAGGSAPKHV QQLVEENYLR 600
    WDSLGEFLAL AVSLEETGIK TGNAKAKLLG KALDEATGKL LDNNKSPSRK 650
    VGDIDNRGSH FYLAMYWAQA LAAQDEDAEL KAHFAPLAKA LTEQEATIVA 700
    ELNAVQGKPA EIGGYYRSNP ELTSKVMRPS ATFNAAIDSL A 741
    Length:741
    Mass (Da):81,594
    Last modified:February 10, 2009 - v1
    Checksum:i64877E2476BBA6F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM209186 Genomic DNA. Translation: CAW27207.1.
    RefSeqiYP_002440081.1. NC_011770.1.

    Genome annotation databases

    EnsemblBacteriaiCAW27207; CAW27207; PLES_24811.
    GeneIDi7176975.
    KEGGipag:PLES_24811.
    PATRICi19814663. VBIPseAer113719_2571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM209186 Genomic DNA. Translation: CAW27207.1 .
    RefSeqi YP_002440081.1. NC_011770.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557722.PLES_24811.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAW27207 ; CAW27207 ; PLES_24811 .
    GeneIDi 7176975.
    KEGGi pag:PLES_24811.
    PATRICi 19814663. VBIPseAer113719_2571.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi SIVKLMQ.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci PAER557722:GHJW-2517-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa."
      Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C.
      Genome Res. 19:12-23(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LESB58Imported.

    Entry informationi

    Entry nameiB7UV17_PSEA8
    AccessioniPrimary (citable) accession number: B7UV17
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 10, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3