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B7UV17

- B7UV17_PSEA8

UniProt

B7UV17 - B7UV17_PSEA8

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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

idh

Organism
Pseudomonas aeruginosa (strain LESB58)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461SubstrateUniRule annotation
Sitei255 – 2551Critical for catalysisUniRule annotation
Metal bindingi350 – 3501Magnesium or manganese
Sitei420 – 4201Critical for catalysisUniRule annotation
Binding sitei547 – 5471SubstrateUniRule annotation
Metal bindingi548 – 5481Magnesium or manganese
Metal bindingi552 – 5521Magnesium or manganese

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPAER557722:GHJW-2517-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported
Gene namesi
Name:idhImported
Ordered Locus Names:PLES_24811Imported
OrganismiPseudomonas aeruginosa (strain LESB58)Imported
Taxonomic identifieri557722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001527: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi557722.PLES_24811.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1408Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiSIVKLMQ.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

B7UV17 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIRSKITYT FTDEAPALAT YSLLPIVKAF AASAGIDVET SDISLAGRIL
60 70 80 90 100
ANFADRLEAD QRIEDDLARL AALATSPDAN IIKLPNISAS VPQLKGAIAE
110 120 130 140 150
LQGLGYKVPD FPEDPQTDEE KEVRARYAKI LGSAVNPVLR EGNSDRRAPA
160 170 180 190 200
AVKAYARKHP HSMGKWSMAS RSHADYMRGG DFFSSEQSIT MAKAGDVRIE
210 220 230 240 250
FVGKDGKVEV KKQLSLQEGE VLDSMFMSCG KLRDFFEKTL QDCKETGVMW
260 270 280 290 300
SLHVKATMMK ISHPIVFGHA VSVYYKDVFD KWGQLFEELG VNPNNGISSV
310 320 330 340 350
YDKIKSLPAS QQEEILHDIH EVYSHRPEMA MVDSVKGITN LHIPSDVIVD
360 370 380 390 400
ASMPAMIRNS GQMWGKDGKQ KDTKAVMPES TYARIYQEMI NFCKTNGAFD
410 420 430 440 450
PTTMGSVPNV GLMAQKAEEY GSHDKTFEMT ADGTMRVVLA DGSVLMQHDV
460 470 480 490 500
ETGDIWRACQ TKDAPIRDWV KLAVTRARQS DTPAIFWLDP ERAHDRELRK
510 520 530 540 550
KVELYLKDHD LTGLDISIMG YNEAIRVSME RLIRGKDTIS VTGNVLRDYL
560 570 580 590 600
TDLFPIMELG TSAKMLSIVP LMAGGGMYET GAGGSAPKHV QQLVEENYLR
610 620 630 640 650
WDSLGEFLAL AVSLEETGIK TGNAKAKLLG KALDEATGKL LDNNKSPSRK
660 670 680 690 700
VGDIDNRGSH FYLAMYWAQA LAAQDEDAEL KAHFAPLAKA LTEQEATIVA
710 720 730 740
ELNAVQGKPA EIGGYYRSNP ELTSKVMRPS ATFNAAIDSL A
Length:741
Mass (Da):81,594
Last modified:February 10, 2009 - v1
Checksum:i64877E2476BBA6F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM209186 Genomic DNA. Translation: CAW27207.1.
RefSeqiYP_002440081.1. NC_011770.1.

Genome annotation databases

EnsemblBacteriaiCAW27207; CAW27207; PLES_24811.
GeneIDi7176975.
KEGGipag:PLES_24811.
PATRICi19814663. VBIPseAer113719_2571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM209186 Genomic DNA. Translation: CAW27207.1 .
RefSeqi YP_002440081.1. NC_011770.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557722.PLES_24811.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAW27207 ; CAW27207 ; PLES_24811 .
GeneIDi 7176975.
KEGGi pag:PLES_24811.
PATRICi 19814663. VBIPseAer113719_2571.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi SIVKLMQ.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci PAER557722:GHJW-2517-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa."
    Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C.
    Genome Res. 19:12-23(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LESB58Imported.

Entry informationi

Entry nameiB7UV17_PSEA8
AccessioniPrimary (citable) accession number: B7UV17
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3