B7UV17 (B7UV17_PSEA8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase EMBL CAW27207.1

Gene names

Name:	idh EMBL CAW27207.1
Ordered Locus Names:	PLES_24811

Organism

Pseudomonas aeruginosa (strain LESB58) [Complete proteome] [HAMAP]

Taxonomic identifier

557722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa group › Pseudomonas aeruginosa

Protein attributes

Sequence length	741 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	133 – 140	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	350	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	548	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	552	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	146	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	547	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	255	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	420	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	B7UV17 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 64877E2476BBA6F6	FASTA	741	81,594
	10 20 30 40 50 60 MSIRSKITYT FTDEAPALAT YSLLPIVKAF AASAGIDVET SDISLAGRIL ANFADRLEAD 70 80 90 100 110 120 QRIEDDLARL AALATSPDAN IIKLPNISAS VPQLKGAIAE LQGLGYKVPD FPEDPQTDEE 130 140 150 160 170 180 KEVRARYAKI LGSAVNPVLR EGNSDRRAPA AVKAYARKHP HSMGKWSMAS RSHADYMRGG 190 200 210 220 230 240 DFFSSEQSIT MAKAGDVRIE FVGKDGKVEV KKQLSLQEGE VLDSMFMSCG KLRDFFEKTL 250 260 270 280 290 300 QDCKETGVMW SLHVKATMMK ISHPIVFGHA VSVYYKDVFD KWGQLFEELG VNPNNGISSV 310 320 330 340 350 360 YDKIKSLPAS QQEEILHDIH EVYSHRPEMA MVDSVKGITN LHIPSDVIVD ASMPAMIRNS 370 380 390 400 410 420 GQMWGKDGKQ KDTKAVMPES TYARIYQEMI NFCKTNGAFD PTTMGSVPNV GLMAQKAEEY 430 440 450 460 470 480 GSHDKTFEMT ADGTMRVVLA DGSVLMQHDV ETGDIWRACQ TKDAPIRDWV KLAVTRARQS 490 500 510 520 530 540 DTPAIFWLDP ERAHDRELRK KVELYLKDHD LTGLDISIMG YNEAIRVSME RLIRGKDTIS 550 560 570 580 590 600 VTGNVLRDYL TDLFPIMELG TSAKMLSIVP LMAGGGMYET GAGGSAPKHV QQLVEENYLR 610 620 630 640 650 660 WDSLGEFLAL AVSLEETGIK TGNAKAKLLG KALDEATGKL LDNNKSPSRK VGDIDNRGSH 670 680 690 700 710 720 FYLAMYWAQA LAAQDEDAEL KAHFAPLAKA LTEQEATIVA ELNAVQGKPA EIGGYYRSNP 730 740 ELTSKVMRPS ATFNAAIDSL A

References

[1]

"Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa." Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C. Genome Res. 19:12-23(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LESB58.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM209186 Genomic DNA. Translation: CAW27207.1.
RefSeq	YP_002440081.1. NC_011770.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	557722.PLES_24811.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAW27207; CAW27207; PLES_24811.
GeneID	7176975.
KEGG	pag:PLES_24811.
PATRIC	19814663. VBIPseAer113719_2571.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2838.
HOGENOM	HOG000240860.
KO	K00031.
OMA	PRTMGTV.
ProtClustDB	CLSK867411.
Enzyme and pathway databases
BioCyc	PAER557722:GHJW-5029-MONOMER.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B7UV17_PSEA8

Accession

Primary (citable) accession number: B7UV17

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)