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B7UV17

- B7UV17_PSEA8

UniProt

B7UV17 - B7UV17_PSEA8

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Protein
Submitted name: Isocitrate dehydrogenase
Gene
idh, PLES_24811
Organism
Pseudomonas aeruginosa (strain LESB58)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461Substrate By similarityUniRule annotation
Sitei255 – 2551Critical for catalysis By similarity
Metal bindingi350 – 3501Magnesium or manganese By similarityUniRule annotation
Sitei420 – 4201Critical for catalysis By similarityUniRule annotation
Binding sitei547 – 5471Substrate By similarityUniRule annotation
Metal bindingi548 – 5481Magnesium or manganese By similarityUniRule annotation
Metal bindingi552 – 5521Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPAER557722:GHJW-2517-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported
Gene namesi
Name:idhImported
Ordered Locus Names:PLES_24811Imported
OrganismiPseudomonas aeruginosa (strain LESB58)Imported
Taxonomic identifieri557722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000001527: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi557722.PLES_24811.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1408Substrate binding By similarityUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiSIVKLMQ.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

B7UV17-1 [UniParc]FASTAAdd to Basket

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MSIRSKITYT FTDEAPALAT YSLLPIVKAF AASAGIDVET SDISLAGRIL    50
ANFADRLEAD QRIEDDLARL AALATSPDAN IIKLPNISAS VPQLKGAIAE 100
LQGLGYKVPD FPEDPQTDEE KEVRARYAKI LGSAVNPVLR EGNSDRRAPA 150
AVKAYARKHP HSMGKWSMAS RSHADYMRGG DFFSSEQSIT MAKAGDVRIE 200
FVGKDGKVEV KKQLSLQEGE VLDSMFMSCG KLRDFFEKTL QDCKETGVMW 250
SLHVKATMMK ISHPIVFGHA VSVYYKDVFD KWGQLFEELG VNPNNGISSV 300
YDKIKSLPAS QQEEILHDIH EVYSHRPEMA MVDSVKGITN LHIPSDVIVD 350
ASMPAMIRNS GQMWGKDGKQ KDTKAVMPES TYARIYQEMI NFCKTNGAFD 400
PTTMGSVPNV GLMAQKAEEY GSHDKTFEMT ADGTMRVVLA DGSVLMQHDV 450
ETGDIWRACQ TKDAPIRDWV KLAVTRARQS DTPAIFWLDP ERAHDRELRK 500
KVELYLKDHD LTGLDISIMG YNEAIRVSME RLIRGKDTIS VTGNVLRDYL 550
TDLFPIMELG TSAKMLSIVP LMAGGGMYET GAGGSAPKHV QQLVEENYLR 600
WDSLGEFLAL AVSLEETGIK TGNAKAKLLG KALDEATGKL LDNNKSPSRK 650
VGDIDNRGSH FYLAMYWAQA LAAQDEDAEL KAHFAPLAKA LTEQEATIVA 700
ELNAVQGKPA EIGGYYRSNP ELTSKVMRPS ATFNAAIDSL A 741
Length:741
Mass (Da):81,594
Last modified:February 10, 2009 - v1
Checksum:i64877E2476BBA6F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM209186 Genomic DNA. Translation: CAW27207.1.
RefSeqiYP_002440081.1. NC_011770.1.

Genome annotation databases

EnsemblBacteriaiCAW27207; CAW27207; PLES_24811.
GeneIDi7176975.
KEGGipag:PLES_24811.
PATRICi19814663. VBIPseAer113719_2571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM209186 Genomic DNA. Translation: CAW27207.1 .
RefSeqi YP_002440081.1. NC_011770.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557722.PLES_24811.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAW27207 ; CAW27207 ; PLES_24811 .
GeneIDi 7176975.
KEGGi pag:PLES_24811.
PATRICi 19814663. VBIPseAer113719_2571.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi SIVKLMQ.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci PAER557722:GHJW-2517-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool epidemic strain of Pseudomonas aeruginosa."
    Winstanley C., Langille M.G.I., Fothergill J.L., Kukavica-Ibrulj I., Paradis-Bleau C., Sanschagrin F., Thomson N.R., Winsor G.L., Quail M.A., Lennard N., Bignell A., Clarke L., Seeger K., Saunders D., Harris D., Parkhill J., Hancock R.E.W., Brinkman F.S.L., Levesque R.C.
    Genome Res. 19:12-23(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LESB58Imported.

Entry informationi

Entry nameiB7UV17_PSEA8
AccessioniPrimary (citable) accession number: B7UV17
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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