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Protein

5-hydroxyisourate hydrolase

Gene

yedX

Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Purine metabolismUniRule annotation

Enzyme and pathway databases

BioCyciECOL574521:GJAO-2150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxyisourate hydrolaseUniRule annotation (EC:3.5.2.17UniRule annotation)
Short name:
HIU hydrolaseUniRule annotation
Short name:
HIUHaseUniRule annotation
Gene namesi
Name:yedXImported
Ordered Locus Names:E2348C_2081Imported
OrganismiEscherichia coli O127:H6 (strain E2348/69 / EPEC)Imported
Taxonomic identifieri574521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000008205 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 1371145-hydroxyisourate hydrolaseSequence analysisPRO_5002864873Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 136113TR_THYInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000251776.
KOiK07127.
OMAiPWAYSTY.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
TIGRFAMsiTIGR02962. hdxy_isourate. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7USY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKRYLVLSV ATAAFSLPSL VYAAQQNILS VHILNQQTGK PAADVAVTLE
60 70 80 90 100
KKADNGWLQL NTAKTDKDGR IKALWPEQTA TTGDYRVVFK TGDYFKKQNL
110 120 130
ESFFPEIPVE FHINKVNEHY HVPLLLSQYG YSTYRGS
Length:137
Mass (Da):15,479
Last modified:February 10, 2009 - v1
Checksum:i0836235A3042E0AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM180568 Genomic DNA. Translation: CAS09629.1.
RefSeqiWP_000920124.1. NC_011601.1.

Genome annotation databases

EnsemblBacteriaiCAS09629; CAS09629; E2348C_2081.
KEGGiecg:E2348C_2081.
PATRICi18343241. VBIEscCol90278_2142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM180568 Genomic DNA. Translation: CAS09629.1.
RefSeqiWP_000920124.1. NC_011601.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAS09629; CAS09629; E2348C_2081.
KEGGiecg:E2348C_2081.
PATRICi18343241. VBIEscCol90278_2142.

Phylogenomic databases

HOGENOMiHOG000251776.
KOiK07127.
OMAiPWAYSTY.

Enzyme and pathway databases

BioCyciECOL574521:GJAO-2150-MONOMER.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
TIGRFAMsiTIGR02962. hdxy_isourate. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7USY0_ECO27
AccessioniPrimary (citable) accession number: B7USY0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: September 7, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.