B7UQK7 (B7UQK7_ECO27) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
L-ribulose-5-phosphate 4-epimerase UlaF HAMAP MF_01952
EC=5.1.3.4 HAMAP MF_01952

Alternative name(s):
L-ascorbate utilization protein F HAMAP MF_01952
Phosphoribulose isomerase HAMAP MF_01952

Gene names

Name:	ulaF HAMAP MF_01952 EMBL CAS12069.1
Ordered Locus Names:	E2348C_4521 EMBL CAS12069.1

Organism

Escherichia coli O127:H6 (strain E2348/69 / EPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

574521 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization By similarity. HAMAP MF_01952
Catalytic activity	L-ribulose 5-phosphate = D-xylulose 5-phosphate. HAMAP MF_01952
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_01952
Pathway	Cofactor degradation; L-ascorbate degradation; D-xylulose 5-phosphate from L-ascorbate: step 4/4. HAMAP MF_01952
Induction	Induced by L-ascorbate. Repressed by UlaR By similarity. HAMAP MF_01952
Sequence similarities	Belongs to the aldolase class II family. AraD/FucA subfamily. HAMAP MF_01952

Ontologies

Keywords
Ligand	Metal-binding HAMAP MF_01952 Zinc HAMAP MF_01952
Molecular function	Isomerase HAMAP MF_01952
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-ascorbic acid metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-ribulose-phosphate 4-epimerase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	74	1	Zinc By similarity HAMAP MF_01952
	Metal binding	93	1	Zinc By similarity HAMAP MF_01952
	Metal binding	95	1	Zinc By similarity HAMAP MF_01952
	Metal binding	165	1	Zinc By similarity HAMAP MF_01952

Sequences

	Sequence		Length	Mass (Da)
	B7UQK7 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 9AC8A8DCAF1FEFEE	FASTA	226	25,080
	10 20 30 40 50 60 MQKLKQQVFE ANMELPRYGL VTFTWGNVSA IDRERGLVVI KPSGVAYETM KADDMVVVDM 70 80 90 100 110 120 SGKVVEGEYR PSSDTATHLE LYRRYPSLGG IVHTHSTHAT AWAQAGLAIP ALGTTHADYF 130 140 150 160 170 180 FGDIPCTRGL SEVQGEYELN TGKVIIETLG NAEPLHTPGI VVYQHGPFAW GKDAHDAVHN 190 200 210 220 AVVMEEVAKM AWIARGINPQ LNHIDSYLMN KHFMRKHGPN AYYGQK

References

[1]

"Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69." Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G. J. Bacteriol. 191:347-354(2009) [PubMed: 18952797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E2348/69 / EPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM180568 Genomic DNA. Translation: CAS12069.1.
RefSeq	YP_002331973.1. NC_011601.1.
3D structure databases
ProteinModelPortal	B7UQK7.
ModBase	Search...
Protein-protein interaction databases
STRING	B7UQK7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000114020; EBESCP00000108491; EBESCG00000113898.
GeneID	7062320.
GenomeReviews	Gene locus E2348_C_4521 in contig FM180568_GR.
KEGG	ecg:E2348C_4521.
PATRIC	18348348. VBIEscCol90278_4626.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000009319.
HOGENOM	HBG541069.
OMA	IDSYLMN.
ProtClustDB	PRK12348.
Family and domain databases
HAMAP	MF_01952. UlaF. [Tree]
InterPro	IPR001303. Aldolase_II/adducin_N. IPR023499. UlaF. [Graphical view]
Gene3D	G3DSA:3.40.225.10. Aldolase_II/adducin_N. 1 hit.
KO	K03077.
Pfam	PF00596. Aldolase_II. 1 hit. [Graphical view]
SMART	SM01007. Aldolase_II. 1 hit. [Graphical view]
SUPFAM	SSF53639. Aldolase_II_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B7UQK7_ECO27

Accession

Primary (citable) accession number: B7UQK7

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)