Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B7UJS9 (MURA_ECO27) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Short name=EPT
Gene names
Name:murA
Ordered Locus Names:E2348C_3468
OrganismEscherichia coli O127:H6 (strain E2348/69 / EPEC) [Complete proteome] [HAMAP]
Taxonomic identifier574521 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111
PRO_1000192083

Sites

Active site1151Proton donor By similarity

Amino acid modifications

Modified residue11512-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

Sequence LengthMass (Da)Tools
B7UJS9 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 6B75A842255E53F7

FASTA41944,818
        10         20         30         40         50         60 
MDKFRVQGPT KLQGEVTISG AKNAALPILF AALLAEEPVE IQNVPKLKDV DTSMKLLSQL 

        70         80         90        100        110        120 
GAKVERNGSV HIDARDVNVF CAPYDLVKTM RASIWALGPL VARFGQGQVS LPGGCTIGAR 

       130        140        150        160        170        180 
PVDLHISGLE QLGATIKLEE GYVKASVDGR LKGAHIVMDK VSVGATVTIM CAATLAEGTT 

       190        200        210        220        230        240 
IIENAAREPE IVDTANFLIT LGAKISGQGT DRIVIEGVER LGGGVYRVLP DRIETGTFLV 

       250        260        270        280        290        300 
AAAISRGKII CRNAQPDTLD AVLAKLRDAG ADIEVGEDWI SLDMHGKRPK AVNVRTAPHP 

       310        320        330        340        350        360 
AFPTDMQAQF TLLNLVAEGT GFITETVFEN RFMHVPELSR MGAHAEIESN TVICHGVEKL 

       370        380        390        400        410 
SGAQVMATDL RASASLVLAG CIAEGTTVVD RIYHIDRGYE RIEDKLRALG ANIERVKGE 

« Hide

References

[1]"Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69."
Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.
J. Bacteriol. 191:347-354(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: E2348/69 / EPEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM180568 Genomic DNA. Translation: CAS11016.1.
RefSeqYP_002330936.1. NC_011601.1.

3D structure databases

ProteinModelPortalB7UJS9.
SMRB7UJS9. Positions 1-419.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING574521.E2348C_3468.

Chemistry

BindingDBB7UJS9.

Proteomic databases

PRIDEB7UJS9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAS11016; CAS11016; E2348C_3468.
GeneID7062710.
KEGGecg:E2348C_3468.
PATRIC18346106. VBIEscCol90278_3542.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0766.
KOK00790.
OMAHGLEQMG.
OrthoDBEOG68M4GK.

Enzyme and pathway databases

BioCycECOL574521:GJAO-3596-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA_ECO27
AccessionPrimary (citable) accession number: B7UJS9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways