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B7UJ18

- B7UJ18_ECO27

UniProt

B7UJ18 - B7UJ18_ECO27

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Protein
Submitted name:

Pyruvate formate-lyase 4/2-ketobutyrate formate-lyase

Gene
tdcE, E2348C_3404
Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei423 – 4231S-acetylcysteine intermediate By similarityUniRule annotation
Active sitei424 – 4241Cysteine radical intermediate By similarityUniRule annotation

GO - Molecular functioni

  1. formate C-acetyltransferase activity Source: InterPro
  2. lyase activity Source: UniProtKB-KW

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciECOL574521:GJAO-3527-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Pyruvate formate-lyase 4/2-ketobutyrate formate-lyaseImported
Gene namesi
Name:tdcEImported
Ordered Locus Names:E2348C_3404Imported
OrganismiEscherichia coli O127:H6 (strain E2348/69 / EPEC)Imported
Taxonomic identifieri574521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000008205: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei739 – 7391Glycine radical By similarityUniRule annotation

Keywords - PTMi

Organic radicalUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi574521.E2348C_3404.

Family & Domainsi

Sequence similaritiesi

Contains glycine radical domain.SAAS annotations

Phylogenomic databases

eggNOGiCOG1882.
HOGENOMiHOG000011346.
KOiK00656.
OMAiFDAYGRE.
OrthoDBiEOG6Q8J0J.

Family and domain databases

InterProiIPR005949. Form_AcTrfase.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR004184. PFL_dom.
[Graphical view]
PfamiPF01228. Gly_radical. 1 hit.
PF02901. PFL. 1 hit.
[Graphical view]
PIRSFiPIRSF000379. For_Ac_trans_1. 1 hit.
TIGRFAMsiTIGR01255. pyr_form_ly_1. 1 hit.
PROSITEiPS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.
PS51554. PFL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7UJ18-1 [UniParc]FASTAAdd to Basket

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MKVDIDTSDK LYADAWLGFK GTDWKNEINV RDFIQHNYTP YEGDESFLAE    50
ATPATTELWE KVMEGIRIEN ATHAPLDFDT NIATTITAHD AGYIDQPLEK 100
IVGLQTDAPL KRALHPFGGI NMIRSSFHAY GREMDSEFEY IFTDLRKTHN 150
QGVFDVYSPD MLRCRKSGVL TGLPDGYGRG RIIGDYRRVA LYGISYLVRE 200
RELQFADLQS RLEKGEDLEA TIRLREELAE HRRALLQIQE MAAKYGFDIS 250
RPAQNAQEAV QWIYFAYLAA VKSQNGGAMS LGRTASFLDI YIERDFKAGV 300
LNEQQAQELI DHFIMKIRMV RFLRTPEFDS LFSGDPIWAT EVIGGMGLDG 350
RTLVTKNSFR YLHTLHTMGP APEPNLTILW SEALPIAFKK YAAQVSIVTS 400
SLQYENDDLM RTDFNSDDYA IACCVSPMVI GKQMQFFGAR ANLAKTLLYA 450
INGGMDEKLK IQVGPKTAPL MDDVLDYDKV MDSLDHFMDW LAVQYISALN 500
IIHYMHDKYS YEASLMALHD RDVYRTMACG IAGLSVATDS LSAIKYARVK 550
PIRDENGLAV DFEIDGEYPQ YGNNDERVDS IACDLVERFM KKIKALPTYR 600
NAVPTQSILT ITSNVVYGQK TGNTPDGRRA GTPFAPGANP MHGRDRKGAV 650
ASLTSVAKLP FTYAKDGISY TFSIVPAALG KEDPIRKTNL VGLLDGYFHH 700
EADVEGGQHL NVNVMNREML LDAIEHPEKY PNLTIRVSGY AVRFNALTRE 750
QQQDVISRTF TQAL 764
Length:764
Mass (Da):85,986
Last modified:February 10, 2009 - v1
Checksum:i34BA82D5865CBFB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM180568 Genomic DNA. Translation: CAS10952.1.
RefSeqiYP_002330872.1. NC_011601.1.

Genome annotation databases

EnsemblBacteriaiCAS10952; CAS10952; E2348C_3404.
GeneIDi7061770.
KEGGiecg:E2348C_3404.
PATRICi18345968. VBIEscCol90278_3475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM180568 Genomic DNA. Translation: CAS10952.1 .
RefSeqi YP_002330872.1. NC_011601.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 574521.E2348C_3404.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAS10952 ; CAS10952 ; E2348C_3404 .
GeneIDi 7061770.
KEGGi ecg:E2348C_3404.
PATRICi 18345968. VBIEscCol90278_3475.

Phylogenomic databases

eggNOGi COG1882.
HOGENOMi HOG000011346.
KOi K00656.
OMAi FDAYGRE.
OrthoDBi EOG6Q8J0J.

Enzyme and pathway databases

BioCyci ECOL574521:GJAO-3527-MONOMER.

Family and domain databases

InterProi IPR005949. Form_AcTrfase.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR004184. PFL_dom.
[Graphical view ]
Pfami PF01228. Gly_radical. 1 hit.
PF02901. PFL. 1 hit.
[Graphical view ]
PIRSFi PIRSF000379. For_Ac_trans_1. 1 hit.
TIGRFAMsi TIGR01255. pyr_form_ly_1. 1 hit.
PROSITEi PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.
PS51554. PFL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69."
    Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.
    J. Bacteriol. 191:347-354(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E2348/69 / EPEC.

Entry informationi

Entry nameiB7UJ18_ECO27
AccessioniPrimary (citable) accession number: B7UJ18
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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