B7UH18 (GRCA_ECO27) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autonomous glycyl radical cofactor

Gene names

Name:	grcA
Ordered Locus Names:	E2348C_2856

Organism

Escherichia coli O127:H6 (strain E2348/69 / EPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

574521 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli › Escherichia coli O127:H6

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Acts as a radical domain for damaged PFL and possibly other radical proteins By similarity. HAMAP-Rule MF_00806
Sequence similarities	Contains 1 glycine radical domain.

Ontologies

Keywords
PTM	Acetylation Organic radical
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 127	127	Autonomous glycyl radical cofactor HAMAP-Rule MF_00806		PRO_1000148567
Regions
	Domain	5 – 127	123	Glycine radical
Amino acid modifications
	Modified residue	48	1	N6-acetyllysine By similarity
	Modified residue	88	1	N6-acetyllysine By similarity
	Modified residue	92	1	N6-acetyllysine By similarity
	Modified residue	102	1	Glycine radical By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7UH18 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 6BB8F8F88C8A5E21	FASTA	127	14,268
	10 20 30 40 50 60 MITGIQITKA ANDDLLNSFW LLDSEKGEAR CIVAKAGFAE DEVVAVSKLG DIEYREVPVE 70 80 90 100 110 120 VKPEVRVEGG QHLNVNVLRR ETLEDAVKHP EKYPQLTIRV SGYAVRFNSL TPEQQRDVIA RTFTESL

References

[1]

"Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69." Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G. J. Bacteriol. 191:347-354(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E2348/69 / EPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM180568 Genomic DNA. Translation: CAS10404.1.
RefSeq	YP_002330353.1. NC_011601.1.
3D structure databases
ProteinModelPortal	B7UH18.
SMR	B7UH18. Positions 13-127.
ModBase	Search...
Protein-protein interaction databases
STRING	574521.E2348C_2856.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAS10404; CAS10404; E2348C_2856.
GeneID	7065079.
KEGG	ecg:E2348C_2856.
PATRIC	18344790. VBIEscCol90278_2900.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3445.
KO	K06866.
OMA	QARCVCA.
ProtClustDB	PRK11127.
Enzyme and pathway databases
BioCyc	ECOL574521:GJAO-2950-MONOMER.
Family and domain databases
HAMAP	MF_00806. GrcA.
InterPro	IPR019777. Form_AcTrfase_GR_CS. IPR001150. Gly_radical. IPR011140. Glycyl_radical_cofactor_YfiD. [Graphical view]
Pfam	PF01228. Gly_radical. 1 hit. [Graphical view]
PIRSF	PIRSF000378. Gly_radicl_yfiD. 1 hit.
PROSITE	PS00850. GLY_RADICAL_1. 1 hit. PS51149. GLY_RADICAL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GRCA_ECO27

Accession

Primary (citable) accession number: B7UH18

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program