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B7UFR8

- ARND_ECO27

UniProt

B7UFR8 - ARND_ECO27

Protein

Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

Gene

arnD

Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

    Catalytic activityi

    4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. lipid A biosynthetic process Source: UniProtKB-HAMAP
    3. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
    4. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciECOL574521:GJAO-2479-MONOMER.
    UniPathwayiUPA00030.
    UPA00036; UER00496.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation)
    Gene namesi
    Name:arnDUniRule annotation
    Ordered Locus Names:E2348C_2400
    OrganismiEscherichia coli O127:H6 (strain E2348/69 / EPEC)
    Taxonomic identifieri574521 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000008205: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDPRO_0000383501Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi574521.E2348C_2400.

    Structurei

    3D structure databases

    ProteinModelPortaliB7UFR8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 260259NodB homologyUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.UniRule annotation
    Contains 1 NodB homology domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0726.
    KOiK13014.
    OMAiLHAWDHF.
    OrthoDBiEOG6423D0.

    Family and domain databases

    Gene3Di3.20.20.370. 2 hits.
    HAMAPiMF_01870. ArnD.
    InterProiIPR023557. ArnD.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR002509. Polysac_deacetylase.
    [Graphical view]
    PfamiPF01522. Polysacc_deac_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF88713. SSF88713. 2 hits.
    PROSITEiPS51677. NODB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7UFR8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKVGLRIDV DTFRGTREGV PRLLEILSKH NIQASIFFSV GPDNMGRHLW    50
    RLVKPQFLWK MLRSNAASLY GWDILLAGTA WPGKEIGHAN ADIIREAAKH 100
    HEVGLHAWDH HAWQAHSGNW DRQTMIDDIA RGLRTLEEII GQPVTCSAAA 150
    GWRADQQVIE AKEAFHLRYN SDCRGAMPFR PLLESGTPGT AQIPVTLPTW 200
    DEVIGRDVKA EDFNGWLLNR IQRDKGTPVY TIHAEVEGCA YQHNFVDLLK 250
    RAAQEGVTFC PLSELLSGTL PLGQVVRGNI AGREGWLGCQ QIAGSH 296
    Length:296
    Mass (Da):33,004
    Last modified:February 10, 2009 - v1
    Checksum:i01011307416CCC6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM180568 Genomic DNA. Translation: CAS09948.1.
    RefSeqiYP_002329904.1. NC_011601.1.

    Genome annotation databases

    EnsemblBacteriaiCAS09948; CAS09948; E2348C_2400.
    GeneIDi7061385.
    KEGGiecg:E2348C_2400.
    PATRICi18343891. VBIEscCol90278_2461.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM180568 Genomic DNA. Translation: CAS09948.1 .
    RefSeqi YP_002329904.1. NC_011601.1.

    3D structure databases

    ProteinModelPortali B7UFR8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 574521.E2348C_2400.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAS09948 ; CAS09948 ; E2348C_2400 .
    GeneIDi 7061385.
    KEGGi ecg:E2348C_2400.
    PATRICi 18343891. VBIEscCol90278_2461.

    Phylogenomic databases

    eggNOGi COG0726.
    KOi K13014.
    OMAi LHAWDHF.
    OrthoDBi EOG6423D0.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00036 ; UER00496 .
    BioCyci ECOL574521:GJAO-2479-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.370. 2 hits.
    HAMAPi MF_01870. ArnD.
    InterProi IPR023557. ArnD.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR002509. Polysac_deacetylase.
    [Graphical view ]
    Pfami PF01522. Polysacc_deac_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF88713. SSF88713. 2 hits.
    PROSITEi PS51677. NODB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69."
      Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.
      J. Bacteriol. 191:347-354(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: E2348/69 / EPEC.

    Entry informationi

    Entry nameiARND_ECO27
    AccessioniPrimary (citable) accession number: B7UFR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3