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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:E2348C_2355
OrganismiEscherichia coli O127:H6 (strain E2348/69 / EPEC)
Taxonomic identifieri574521 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000008205 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001247681 – 548Probable malate:quinone oxidoreductaseAdd BLAST548

Proteomic databases

PRIDEiB7UFM4.

Structurei

3D structure databases

ProteinModelPortaliB7UFM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

KOiK00116.
OMAiEPIAATK.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00212. MQO. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR006231. MQO.
PfamiView protein in Pfam
PF06039. Mqo. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

B7UFM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVTAMLFS MAVGLNAVSM AAKVKASEEQ ETDVLLIGGG IMSATLGTYL
60 70 80 90 100
RELEPEWSMT MVERLEGVAQ ESSNGWNNAG TGHSALMELN YTPQNVDGSI
110 120 130 140 150
SIEKAVAINE AFQISRQFWA HQVERGVLRT PRSFINTVPH MSFVWGEDNV
160 170 180 190 200
NFLRARYAAL QQSSLFRGMR YSEDHAQIKE WAPLVMEGRD PQQKVAATRT
210 220 230 240 250
EIGTDVNYGE ITRQLIASLQ KKSNFSLQLS SEVRALKRND DNSWTVTVAD
260 270 280 290 300
LKNGTAQNIR AKFVFIGAGG AALKLLQESG IPEAKDYAGF PVGGQFLVSE
310 320 330 340 350
NPDVVNHHLA KVYGKASVGA PPMSVPHIDT RVLDGKRVVL FGPFATFSTK
360 370 380 390 400
FLKNGSLWDL MSSTTTSNVM PMMHVGLDNF DLVKYLVSQV MLSEEDRFEA
410 420 430 440 450
LKEYYPQAKK EDWRLWQAGQ RVQIIKRDAD KGGVLRLGTE VVSDQQGTIA
460 470 480 490 500
ALLGASPGAS TAAPIMLNLL EKVFGDRVSS PQWQATLKAI VPSYGRKLNG
510 520 530 540
DVAATERELQ YTSEVLGLKY DKPQAVDSTP KPQLKPQLVQ KEVADIAL
Length:548
Mass (Da):60,316
Last modified:February 10, 2009 - v1
Checksum:iC9AA857A7F2911F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM180568 Genomic DNA. Translation: CAS09903.1.
RefSeqiWP_000758091.1. NC_011601.1.

Genome annotation databases

EnsemblBacteriaiCAS09903; CAS09903; E2348C_2355.
KEGGiecg:E2348C_2355.

Similar proteinsi

Entry informationi

Entry nameiMQO_ECO27
AccessioniPrimary (citable) accession number: B7UFM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: October 25, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families