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Protein
Submitted name:

Pol protein

Gene

pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.SAAS annotation
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl proteaseUniRule annotationSAAS annotation, DNA-bindingSAAS annotation, EndonucleaseSAAS annotation, Hydrolase, Multifunctional enzymeSAAS annotation, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase
Biological processDNA integration, DNA recombinationSAAS annotation, Viral genome integrationSAAS annotation, Virus entry into host cell
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Pol proteinImported
Gene namesi
Name:polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 141Peptidase A2InterPro annotationAdd BLAST70
Domaini195 – 385Reverse transcriptaseInterPro annotationAdd BLAST191

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili640 – 660Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerSAAS annotation

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di2.40.70.10, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
IPR000477 RT_dom
IPR010659 RVT_connect
IPR010661 RVT_thumb
PfamiView protein in Pfam
PF00075 RNase_H, 1 hit
PF00077 RVP, 1 hit
PF00078 RVT_1, 1 hit
PF06815 RVT_connect, 1 hit
PF06817 RVT_thumb, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
SSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS00141 ASP_PROTEASE, 1 hit
PS50878 RT_POL, 1 hit

Sequencei

Sequence statusi: Fragment.

B7TF68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FFRENLAFPQ GEAREFPSEQ TRANSPTSRE LQVRGDNPRS EAGVERQGTL
60 70 80 90 100
NCPQITLWQR PLVSIKVGGQ VREALLDTGA DDTVLEDIDL PGKWKPRMIG
110 120 130 140 150
GVGGFIKVRQ YEQILIEICG KKAIGTVLVG PTPVNIIGRN MLTQLGCTLN
160 170 180 190 200
FPISPIETIP VKLKPGMDGP KVKQWPLTEE KIKALTAICE EMEKEGKITK
210 220 230 240 250
IGPENPYNTP IFAIKKKDST KWRKLVDFRE LNKRTQDFWE VQLGIPHPAG
260 270 280 290 300
LKKKKSVTVL DVGDAYFSVP LDEGFRKYTA FTIPSINNET PGIRYQYNVL
310 320 330 340 350
PQGWKGSPAI FQSSMTKILE PFRAKNPGII IYQYMDDLYV GSDLEIGQHR
360 370 380 390 400
AKVEELRAHL LRWGFTTPDK KHQKEPPFLW MGYELHPDKW TVQPIQLPEK
410 420 430 440 450
ENWTVNDIQK LVGKLNWASQ IYSGIKVKQL CKLLRGAKAL TDIVPLTEEA
460 470 480 490 500
ELELAENREI LKEPVHGVYY DPSKDLIAEI QKQECGQWSY QIYQEPFKNL
510 520 530 540 550
KTGKYAKMRT AHTNDVKQLT EAVQKIALES IVIWGKTPKF RLPIQKETWE
560 570 580 590 600
RWWTDYWQAT WIPDWEFVNT PPLVKLWYQL EKEPIAGAET FYVDGAANRE
610 620 630 640 650
TKLGKAGYVT DRGRQKVVSI TETTNQKTEL QAIQLVESMN KELKKIIGQV
660 670 680 690
RDQAEHLKQD NSDIKVVPRR KAKIIRDYGK QMAGADCVAG RQDED
Length:695
Mass (Da):79,433
Last modified:February 10, 2009 - v1
Checksum:iFFA031D31C3FA1CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei695Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ199864 Genomic DNA Translation: ACJ25875.1

Similar proteinsi

Entry informationi

Entry nameiB7TF68_9HIV1
AccessioniPrimary (citable) accession number: B7TF68
Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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