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Protein

Fatty acid-binding protein 12

Gene

FABP12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in lipid transport.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071Fatty acidBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-RNO-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein 121 Publication
Gene namesi
Name:FABP121 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1565000. Fabp12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Fatty acid-binding protein 12PRO_0000394457Add
BLAST

Proteomic databases

PaxDbiB7SUM8.

Expressioni

Tissue specificityi

Highly expressed in adult retina and testis with lower levels in cerebral cortex, kidney and epididymis. In the retina, strongly expressed in the ganglion cell layer and throughout the inner nuclear layer in amacrine and bipolar cells. Not expressed in the outer nuclear layer. In the testis, detected in the seminiferous tubules.1 Publication

Developmental stagei

Expressed in adult but not at postnatal day 1. In the seminiferous tubule, expressed in first layer capped spermatids at stage VII and in spermatids closer to the lumen of the tubule at stage XII. Not detected in spermatogonia, first layer of spermatocytes or mature spermatozoa.1 Publication

Gene expression databases

BgeeiENSRNOG00000038825.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056087.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Fatty acid bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiB7SUM8.
OMAiDNDAMIH.
PhylomeDBiB7SUM8.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031261. FABP12.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF76. PTHR11955:SF76. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

B7SUM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDQLQGTWK SVSCENFENY MKELGAGRAI RKLGCLARPV VTISTDGDRI
60 70 80 90 100
TIKTKSIFKN KEISFKLGEE FEEITPGGRK SKSTVVLDND SLVQVQDWDG
110 120 130
KEATIRRRLV DGKMVVESAV NNVTCTRTYQ RV
Length:132
Mass (Da):14,860
Last modified:February 10, 2009 - v1
Checksum:i74F08D017EECAFC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU733648 mRNA. Translation: ACI03638.1.
CH473961 Genomic DNA. Translation: EDM00992.1.
RefSeqiNP_001128086.1. NM_001134614.1.
XP_006232207.1. XM_006232145.2.
XP_006232208.1. XM_006232146.2.
XP_006232209.1. XM_006232147.2.
XP_006232210.1. XM_006232148.2.
UniGeneiRn.229045.

Genome annotation databases

EnsembliENSRNOT00000059326; ENSRNOP00000056087; ENSRNOG00000038825.
ENSRNOT00000077782; ENSRNOP00000072023; ENSRNOG00000038825.
GeneIDi499570.
KEGGirno:499570.
UCSCiRGD:1565000. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU733648 mRNA. Translation: ACI03638.1.
CH473961 Genomic DNA. Translation: EDM00992.1.
RefSeqiNP_001128086.1. NM_001134614.1.
XP_006232207.1. XM_006232145.2.
XP_006232208.1. XM_006232146.2.
XP_006232209.1. XM_006232147.2.
XP_006232210.1. XM_006232148.2.
UniGeneiRn.229045.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056087.

Proteomic databases

PaxDbiB7SUM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000059326; ENSRNOP00000056087; ENSRNOG00000038825.
ENSRNOT00000077782; ENSRNOP00000072023; ENSRNOG00000038825.
GeneIDi499570.
KEGGirno:499570.
UCSCiRGD:1565000. rat.

Organism-specific databases

CTDi646486.
RGDi1565000. Fabp12.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiB7SUM8.
OMAiDNDAMIH.
PhylomeDBiB7SUM8.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-RNO-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

PROiB7SUM8.

Gene expression databases

BgeeiENSRNOG00000038825.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031261. FABP12.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF76. PTHR11955:SF76. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFBP12_RAT
AccessioniPrimary (citable) accession number: B7SUM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: February 10, 2009
Last modified: September 7, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.