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B7R258

- B7R258_9EURY

UniProt

B7R258 - B7R258_9EURY

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Protein
Ribulose bisphosphate carboxylase
Gene
rbcL, TAM4_1764
Organism
Thermococcus sp. AM4
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei163 – 1631Proton acceptor By similarityUniRule annotation
Binding sitei165 – 1651Substrate By similarityUniRule annotation
Metal bindingi189 – 1891Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi191 – 1911Magnesium By similarityUniRule annotation
Metal bindingi192 – 1921Magnesium By similarityUniRule annotation
Active sitei281 – 2811Proton acceptor By similarityUniRule annotation
Binding sitei282 – 2821Substrate By similarityUniRule annotation
Binding sitei314 – 3141Substrate By similarityUniRule annotation
Sitei322 – 3221Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
ORF Names:TAM4_1764Imported
OrganismiThermococcus sp. AM4Imported
Taxonomic identifieri246969 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000009277: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei189 – 1891N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7R258.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni367 – 3693Substrate binding By similarityUniRule annotation
Regioni389 – 3924Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01601.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01133. RuBisCO_L_type3.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

B7R258-1 [UniParc]FASTAAdd to Basket

« Hide

MVEKFDKIYD YYVDKGYEPN KKRDIIAVFR VTPAEGYTIE AAAGAVAAES    50
STGTWTTLYP WYEQERWADL SAKAYDFIDM GDGSWIVRIA YPFHAFEEWN 100
LPGLLASIAG NVFGMKRVKG LRLEDLYIPE IVLRNFNGPA FGIEGVRKML 150
EIYDRPLYGV VPKPKVGYSP EEFEKLAYEL LSNGADYMKD DENLTSPWYN 200
RFDERAEIVA RVIDKVENET GEKKTWFANI TADVREMERR LEILADLGLK 250
HAMVDVVITG WGALEYIRDL AADYGLAIHG HRAMHAAFTR NKYHGISMFV 300
LAKLYRIIGI DQLHVGTAGA GKLEGGKWDV IQNARILREE TYTPDENDVF 350
HLEQKFYGMK PAFPTSSGGL HPGNIEPVIE ALGKDIVLQL GGGTLGHPDG 400
PGAGARAVRQ AIDAIMQGIP LDEYAKTHKE LARALEKWGH VTPV 444
Length:444
Mass (Da):49,807
Last modified:February 10, 2009 - v1
Checksum:i8BD0A123C21ED7CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002952 Genomic DNA. Translation: EEB74397.1.
RefSeqiWP_014122283.1. NC_016051.1.
YP_002582810.1. NC_016051.1.

Genome annotation databases

EnsemblBacteriaiEEB74397; EEB74397; TAM4_1764.
GeneIDi7419691.
KEGGitha:TAM4_1764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002952 Genomic DNA. Translation: EEB74397.1 .
RefSeqi WP_014122283.1. NC_016051.1.
YP_002582810.1. NC_016051.1.

3D structure databases

ProteinModelPortali B7R258.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EEB74397 ; EEB74397 ; TAM4_1764 .
GeneIDi 7419691.
KEGGi tha:TAM4_1764.

Phylogenomic databases

KOi K01601.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01133. RuBisCO_L_type3.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of the Hyperthermophilic Archaeon Thermococcus sp. Strain AM4, Capable of Organotrophic Growth and Growth at the Expense of Hydrogenogenic or Sulfidogenic Oxidation of Carbon Monoxide."
    Oger P., Sokolova T.G., Kozhevnikova D.A., Chernyh N.A., Bartlett D.H., Bonch-Osmolovskaya E.A., Lebedinsky A.V.
    J. Bacteriol. 193:7019-7020(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AM4Imported.

Entry informationi

Entry nameiB7R258_9EURY
AccessioniPrimary (citable) accession number: B7R258
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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