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B7R216

- B7R216_9EURY

UniProt

B7R216 - B7R216_9EURY

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Protein

DNA ligase

Gene
lig, TAM4_1751
Organism
Thermococcus sp. AM4
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei250 – 2501ATP By similarityUniRule annotation
Active sitei252 – 2521N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei257 – 2571ATP By similarityUniRule annotation
Binding sitei272 – 2721ATP By similarityUniRule annotation
Binding sitei302 – 3021ATP By similarityUniRule annotation
Binding sitei342 – 3421ATP By similarityUniRule annotation
Binding sitei417 – 4171ATP By similarityUniRule annotation
Binding sitei423 – 4231ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
ORF Names:TAM4_1751Imported
OrganismiThermococcus sp. AM4Imported
Taxonomic identifieri246969 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000009277: Chromosome

Structurei

3D structure databases

ProteinModelPortaliB7R216.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7R216-1 [UniParc]FASTAAdd to Basket

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MGDMKYLELA ELYRRLEKTT LKTLKTKFVA DFLKKTPDDL LEIVPYLILG    50
KVFPDWDERE LGVGEKLLIR AVSMATGVPE KEIENSIKDT GDLGESVALA 100
LKKRKQKSFF SQPLTIKRVY NTFVKVAEAS GEGSQDRKMK YLANLFMDAT 150
PEEGKYLART VLGTMRTGVA EGILRDAIAE AFKVKPELVE RAYMLTSDFG 200
YVTRVAKLEG NEGLSKVSIQ IGKPIRPMLA QNAANVKEAL IEMGGEAAFE 250
IKYDGARVQV HRDGDRVIIY SRRLENVTRS IPEIVEAVKA SLRPSKVIVE 300
GELVAVGENG RPRPFQYVLR RFRRKYNIEE MIEKIPLELN LFDILYVEGE 350
SLIDTKFAER RKKLEESVEE SDKIKLAEQL VTKKVDEAEE FYKRALELGH 400
EGLMAKRLDS VYEPGNRGKK WLKIKPTMEN LDLVIIGAEW GEGRRAHLLG 450
SFLVAAYDPE SGEFVPVGKV GSGFTDEDLI EFTKMLKPLI VREEGKFVEI 500
QPKVVIEVTY QEIQKSPKYK SGFALRFPRY VALREDKSPE EADTIERVAQ 550
LYELQEKFKA KR 562
Length:562
Mass (Da):63,935
Last modified:February 10, 2009 - v1
Checksum:i516DF59572BDE926
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002952 Genomic DNA. Translation: EEB74384.1.
RefSeqiWP_014122243.1. NC_016051.1.
YP_002582768.1. NC_016051.1.

Genome annotation databases

EnsemblBacteriaiEEB74384; EEB74384; TAM4_1751.
GeneIDi7420290.
KEGGitha:TAM4_1751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002952 Genomic DNA. Translation: EEB74384.1 .
RefSeqi WP_014122243.1. NC_016051.1.
YP_002582768.1. NC_016051.1.

3D structure databases

ProteinModelPortali B7R216.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EEB74384 ; EEB74384 ; TAM4_1751 .
GeneIDi 7420290.
KEGGi tha:TAM4_1751.

Phylogenomic databases

KOi K10747.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of the Hyperthermophilic Archaeon Thermococcus sp. Strain AM4, Capable of Organotrophic Growth and Growth at the Expense of Hydrogenogenic or Sulfidogenic Oxidation of Carbon Monoxide."
    Oger P., Sokolova T.G., Kozhevnikova D.A., Chernyh N.A., Bartlett D.H., Bonch-Osmolovskaya E.A., Lebedinsky A.V.
    J. Bacteriol. 193:7019-7020(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AM4Imported.

Entry informationi

Entry nameiB7R216_9EURY
AccessioniPrimary (citable) accession number: B7R216
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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