Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B7R216

- B7R216_9EURY

UniProt

B7R216 - B7R216_9EURY

Protein

DNA ligase

Gene

lig

Organism
Thermococcus sp. AM4
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei250 – 2501ATPUniRule annotation
    Active sitei252 – 2521N6-AMP-lysine intermediateUniRule annotation
    Binding sitei257 – 2571ATPUniRule annotation
    Binding sitei272 – 2721ATPUniRule annotation
    Binding sitei302 – 3021ATPUniRule annotation
    Binding sitei342 – 3421ATPUniRule annotation
    Binding sitei417 – 4171ATPUniRule annotation
    Binding sitei423 – 4231ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    ORF Names:TAM4_1751Imported
    OrganismiThermococcus sp. AM4Imported
    Taxonomic identifieri246969 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000009277: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliB7R216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7R216-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDMKYLELA ELYRRLEKTT LKTLKTKFVA DFLKKTPDDL LEIVPYLILG    50
    KVFPDWDERE LGVGEKLLIR AVSMATGVPE KEIENSIKDT GDLGESVALA 100
    LKKRKQKSFF SQPLTIKRVY NTFVKVAEAS GEGSQDRKMK YLANLFMDAT 150
    PEEGKYLART VLGTMRTGVA EGILRDAIAE AFKVKPELVE RAYMLTSDFG 200
    YVTRVAKLEG NEGLSKVSIQ IGKPIRPMLA QNAANVKEAL IEMGGEAAFE 250
    IKYDGARVQV HRDGDRVIIY SRRLENVTRS IPEIVEAVKA SLRPSKVIVE 300
    GELVAVGENG RPRPFQYVLR RFRRKYNIEE MIEKIPLELN LFDILYVEGE 350
    SLIDTKFAER RKKLEESVEE SDKIKLAEQL VTKKVDEAEE FYKRALELGH 400
    EGLMAKRLDS VYEPGNRGKK WLKIKPTMEN LDLVIIGAEW GEGRRAHLLG 450
    SFLVAAYDPE SGEFVPVGKV GSGFTDEDLI EFTKMLKPLI VREEGKFVEI 500
    QPKVVIEVTY QEIQKSPKYK SGFALRFPRY VALREDKSPE EADTIERVAQ 550
    LYELQEKFKA KR 562
    Length:562
    Mass (Da):63,935
    Last modified:February 10, 2009 - v1
    Checksum:i516DF59572BDE926
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002952 Genomic DNA. Translation: EEB74384.1.
    RefSeqiWP_014122243.1. NC_016051.1.
    YP_002582768.1. NC_016051.1.

    Genome annotation databases

    EnsemblBacteriaiEEB74384; EEB74384; TAM4_1751.
    GeneIDi7420290.
    KEGGitha:TAM4_1751.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002952 Genomic DNA. Translation: EEB74384.1 .
    RefSeqi WP_014122243.1. NC_016051.1.
    YP_002582768.1. NC_016051.1.

    3D structure databases

    ProteinModelPortali B7R216.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EEB74384 ; EEB74384 ; TAM4_1751 .
    GeneIDi 7420290.
    KEGGi tha:TAM4_1751.

    Phylogenomic databases

    KOi K10747.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of the Hyperthermophilic Archaeon Thermococcus sp. Strain AM4, Capable of Organotrophic Growth and Growth at the Expense of Hydrogenogenic or Sulfidogenic Oxidation of Carbon Monoxide."
      Oger P., Sokolova T.G., Kozhevnikova D.A., Chernyh N.A., Bartlett D.H., Bonch-Osmolovskaya E.A., Lebedinsky A.V.
      J. Bacteriol. 193:7019-7020(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AM4Imported.

    Entry informationi

    Entry nameiB7R216_9EURY
    AccessioniPrimary (citable) accession number: B7R216
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 10, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3