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Protein

DNA ligase

Gene

lig

Organism
Thermococcus sp. AM4
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation
NAD+ + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + beta-nicotinamide D-nucleotide.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei250ATPUniRule annotation1
Active sitei252N6-AMP-lysine intermediateUniRule annotation1
Binding sitei257ATPUniRule annotation1
Binding sitei272ATPUniRule annotation1
Binding sitei302ATPUniRule annotation1
Binding sitei342ATPUniRule annotation1
Binding sitei417ATPUniRule annotation1
Binding sitei423ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, NADUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.6UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP/NAD(+)]UniRule annotation
Gene namesi
Name:ligUniRule annotation
ORF Names:TAM4_1751Imported
OrganismiThermococcus sp. AM4Imported
Taxonomic identifieri246969 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000009277 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi246969.TAM4_1751

Structurei

3D structure databases

ProteinModelPortaliB7R216
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini330 – 458DNA_LIGASE_A3InterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

B7R216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDMKYLELA ELYRRLEKTT LKTLKTKFVA DFLKKTPDDL LEIVPYLILG
60 70 80 90 100
KVFPDWDERE LGVGEKLLIR AVSMATGVPE KEIENSIKDT GDLGESVALA
110 120 130 140 150
LKKRKQKSFF SQPLTIKRVY NTFVKVAEAS GEGSQDRKMK YLANLFMDAT
160 170 180 190 200
PEEGKYLART VLGTMRTGVA EGILRDAIAE AFKVKPELVE RAYMLTSDFG
210 220 230 240 250
YVTRVAKLEG NEGLSKVSIQ IGKPIRPMLA QNAANVKEAL IEMGGEAAFE
260 270 280 290 300
IKYDGARVQV HRDGDRVIIY SRRLENVTRS IPEIVEAVKA SLRPSKVIVE
310 320 330 340 350
GELVAVGENG RPRPFQYVLR RFRRKYNIEE MIEKIPLELN LFDILYVEGE
360 370 380 390 400
SLIDTKFAER RKKLEESVEE SDKIKLAEQL VTKKVDEAEE FYKRALELGH
410 420 430 440 450
EGLMAKRLDS VYEPGNRGKK WLKIKPTMEN LDLVIIGAEW GEGRRAHLLG
460 470 480 490 500
SFLVAAYDPE SGEFVPVGKV GSGFTDEDLI EFTKMLKPLI VREEGKFVEI
510 520 530 540 550
QPKVVIEVTY QEIQKSPKYK SGFALRFPRY VALREDKSPE EADTIERVAQ
560
LYELQEKFKA KR
Length:562
Mass (Da):63,935
Last modified:February 10, 2009 - v1
Checksum:i516DF59572BDE926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002952 Genomic DNA Translation: EEB74384.1

Genome annotation databases

EnsemblBacteriaiEEB74384; EEB74384; TAM4_1751
KEGGitha:TAM4_1751

Similar proteinsi

Entry informationi

Entry nameiB7R216_9EURY
AccessioniPrimary (citable) accession number: B7R216
Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: March 28, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health