ID   B7QF74_IXOSC            Unreviewed;       158 AA.
AC   B7QF74;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Microsomal glutathione S-transferase, putative {ECO:0000313|EMBL:EEC17496.1, ECO:0000313|EnsemblMetazoa:ISCW012228-PA};
DE            EC=2.5.1.18 {ECO:0000313|EMBL:EEC17496.1};
GN   ORFNames=IscW_ISCW012228 {ECO:0000313|EMBL:EEC17496.1};
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1] {ECO:0000313|EMBL:EEC17496.1, ECO:0000313|Proteomes:UP000001555}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC   {ECO:0000313|EMBL:EEC17496.1};
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ISCW012228-PA}
RP   IDENTIFICATION.
RC   STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW012228-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; ABJB010249122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010646950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010650796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS924414; EEC17496.1; -; Genomic_DNA.
DR   RefSeq; XP_002414188.1; XM_002414143.1.
DR   AlphaFoldDB; B7QF74; -.
DR   STRING; 6945.B7QF74; -.
DR   PaxDb; 6945-B7QF74; -.
DR   EnsemblMetazoa; ISCW012228-RA; ISCW012228-PA; ISCW012228.
DR   KEGG; isc:IscW_ISCW012228; -.
DR   VEuPathDB; VectorBase:ISCI012228; -.
DR   VEuPathDB; VectorBase:ISCP_017262; -.
DR   VEuPathDB; VectorBase:ISCW012228; -.
DR   HOGENOM; CLU_110291_1_0_1; -.
DR   InParanoid; B7QF74; -.
DR   OMA; MARRRYH; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IBA:GO_Central.
DR   GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR   GO; GO:0006691; P:leukotriene metabolic process; IEA:UniProt.
DR   Gene3D; 1.20.120.550; Membrane associated eicosanoid/glutathione metabolism-like domain; 1.
DR   InterPro; IPR023352; MAPEG-like_dom_sf.
DR   InterPro; IPR001129; Membr-assoc_MAPEG.
DR   PANTHER; PTHR10250; MICROSOMAL GLUTATHIONE S-TRANSFERASE; 1.
DR   PANTHER; PTHR10250:SF26; S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08370)-RELATED; 1.
DR   Pfam; PF01124; MAPEG; 1.
DR   SUPFAM; SSF161084; MAPEG domain-like; 1.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:B7QF74};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW   Transferase {ECO:0000313|EMBL:EEC17496.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        28..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        102..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        133..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   158 AA;  17645 MW;  1C98BB7967B179E2 CRC64;
     MRTRKRAKLR KIGGSIMSTL SLVVPKEYGY VVLVGVGSTL VNMWLSIRVG KARRLYDVKY
     PAMYSDTNIV FNCIQRSHQN FLEYYPQFLM VLFLGGIEYP RLAAASGVVF LAGRIVYALG
     YSTGDPAKRM RGGFQYLGLL TLLGLSARLG VRMLGLVH
//