B7Q5F6 (B7Q5F6_IXOSC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Proteasome subunit alpha type RuleBase RU000551
EC=3.4.25.1 RuleBase RU000551

Gene names

ORF Names:

IscW_ISCW021572 EMBL EEC14078.1

Organism

Ixodes scapularis (Black-legged tick) (Deer tick)

Taxonomic identifier

6945 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Acari › Parasitiformes › Ixodida › Ixodoidea › Ixodidae › Ixodinae › Ixodes

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity. RuleBase RU000551
Catalytic activity	Cleavage of peptide bonds with very broad specificity. RuleBase RU000551
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits By similarity. RuleBase RU000551
Subcellular location	Cytoplasm. Nucleus By similarity RuleBase RU000551.
Sequence similarities	Belongs to the peptidase T1A family. RuleBase RU000551

Ontologies

Keywords
Cellular component	Cytoplasm RuleBase RU000551 Nucleus SAAS SAAS000426 RuleBase RU000551 Proteasome RuleBase RU000551 EMBL EEC14078.1
Molecular function	Hydrolase Protease Threonine protease RuleBase RU000551
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell proteasome core complex, alpha-subunit complex Inferred from electronic annotation. Source: InterPro
Molecular function	threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B7Q5F6 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 48EAAFFD509B8FF1	FASTA	246	27,281
	10 20 30 40 50 60 MARGTSAGFD RHITIFSPEG RLYQVEYAFK AINQGALTSI GVKGVDTAVI VSQKKVPDKL 70 80 90 100 110 120 LDPTTVTHIF RLTESIGCVM TGVVADGQSQ VQRARYEAAN WKHKFGYPIP VDMLCRRVAD 130 140 150 160 170 180 ISQVYTQNAE MRPLGCSMML VAYDEERGPQ LYKADPAGYY CGYKATSVGV KQTEANSYLE 190 200 210 220 230 240 KKFKKRQDYN HAETIQLAIS ALSSVLSADF KPSELEVGVV SKDEPLFRTL TEQEIDAHLV AIAEKE

References

[1]

"Annotation of Ixodes scapularis." Ixodes scapularis Genome Project Consortium Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P., Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M., Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A. , Birren B., Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Wikel.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS861322 Genomic DNA. Translation: EEC14078.1.
RefSeq	XP_002411749.1. XM_002411704.1.
UniGene	Isc.17120.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B7Q5F6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ISCW021572-RA; ISCW021572-PA; ISCW021572.
GeneID	8036174.
KEGG	isc:IscW_ISCW021572.
VectorBase	ISCW021572. Ixodes scapularis.
Organism-specific databases
CTD	8036174.
Phylogenomic databases
GeneTree	EMGT00050000009409.
OMA	GKDCAVV.
OrthoDB	EOG4ZW3SZ.
Family and domain databases
InterPro	IPR000426. Proteasome_asu_N. IPR023332. Proteasome_suA-type. IPR001353. Proteasome_sua/b. [Graphical view]
KO	K02730.
Pfam	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
SMART	SM00948. Proteasome_A_N. 1 hit. [Graphical view]
PROSITE	PS00388. PROTEASOME_A_1. 1 hit. PS51475. PROTEASOME_A_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B7Q5F6_IXOSC

Accession

Primary (citable) accession number: B7Q5F6

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)