ID   B7Q505_IXOSC            Unreviewed;       475 AA.
AC   B7Q505;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 99.
DE   RecName: Full=Elongation factor Tu {ECO:0000256|RuleBase:RU000325};
GN   Name=8035998 {ECO:0000313|EnsemblMetazoa:ISCW010766-PA};
GN   ORFNames=IscW_ISCW010766 {ECO:0000313|EMBL:EEC13927.1};
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1] {ECO:0000313|EMBL:EEC13927.1, ECO:0000313|Proteomes:UP000001555}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC   {ECO:0000313|EMBL:EEC13927.1};
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ISCW010766-PA}
RP   IDENTIFICATION.
RC   STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW010766-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC       tRNA to the A-site of ribosomes during protein biosynthesis.
CC       {ECO:0000256|RuleBase:RU000325}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC       subfamily. {ECO:0000256|ARBA:ARBA00007249,
CC       ECO:0000256|RuleBase:RU000325}.
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DR   EMBL; ABJB010777537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS858703; EEC13927.1; -; Genomic_DNA.
DR   RefSeq; XP_002401272.1; XM_002401228.1.
DR   AlphaFoldDB; B7Q505; -.
DR   STRING; 6945.B7Q505; -.
DR   PaxDb; 6945-B7Q505; -.
DR   EnsemblMetazoa; ISCW010766-RA; ISCW010766-PA; ISCW010766.
DR   GeneID; 8035998; -.
DR   KEGG; isc:IscW_ISCW010766; -.
DR   VEuPathDB; VectorBase:ISCI010766; -.
DR   VEuPathDB; VectorBase:ISCP_009593; -.
DR   VEuPathDB; VectorBase:ISCW010766; -.
DR   HOGENOM; CLU_007265_0_0_1; -.
DR   InParanoid; B7Q505; -.
DR   OMA; FHNNYRP; -.
DR   OrthoDB; 167272at2759; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central.
DR   GO; GO:0070125; P:mitochondrial translational elongation; IBA:GO_Central.
DR   CDD; cd01884; EF_Tu; 1.
DR   CDD; cd03697; EFTU_II; 1.
DR   CDD; cd03706; mtEFTU_III; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 2.
DR   InterPro; IPR041709; EF-Tu_GTP-bd.
DR   InterPro; IPR004161; EFTu-like_2.
DR   InterPro; IPR033720; EFTU_2.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR   InterPro; IPR004541; Transl_elong_EFTu/EF1A_bac/org.
DR   InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR   NCBIfam; TIGR00485; EF-Tu; 1.
DR   PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   Pfam; PF03143; GTP_EFTU_D3; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50447; Translation proteins; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   1: Evidence at protein level;
KW   Elongation factor {ECO:0000256|ARBA:ARBA00022768,
KW   ECO:0000256|RuleBase:RU000325};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000325};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000325};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:EEC13927.1};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:B7Q505};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW   Transferase {ECO:0000313|EMBL:EEC13927.1}.
FT   DOMAIN          62..257
FT                   /note="Tr-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51722"
FT   REGION          451..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  52235 MW;  69C999FC1D1002E6 CRC64;
     MTSTLLGRFL CSGSGPLKAV ASKPLVAVPS AAAAACRLWV VLPRRCLATP SPAAKKVYQR
     EKPHCNIGTI GHVDHGKTTL TAAITKVLAE EKLAAAKKYE EIDNAPEEQA RGITINVAHV
     EYSTANRHYG HTDCPGHADY IKNMITGTSQ MDGAILVVAA TDGAMPQTRE HLLLAKQIGI
     EHIVVYLNKA DAADKEMLEL VEIELRELLT EHGYKGDEVP IVTGSALCAL EGREPDLGKD
     SILKLLDTVD SHIPTPQRDL DKPFLMPIES VYSIPGRGTV VTGRLDRGIV KKGMECEIVG
     YNKFFKTTVT GIEMFHKILE EAQAGDQLGA LIRGIKRDEV RRGMVLCKPG TIKQHDQYEA
     QVYVLKKEEG GRERPILKRY QPIVFSTTWD CPARITVEGR DMVMPGEDCK LIVKLFKPMA
     LEQGQRFTLR DGSRTSGTGV VTKVLNNLTP DERADLEKSE KKKEKEALKR AQKGA
//