ID   B7Q222_IXOSC            Unreviewed;       184 AA.
AC   B7Q222;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   RecName: Full=[histone H4]-lysine(20) N-methyltransferase {ECO:0000256|ARBA:ARBA00012187};
DE            EC=2.1.1.361 {ECO:0000256|ARBA:ARBA00012187};
DE   Flags: Fragment;
GN   ORFNames=IscW_ISCW020034 {ECO:0000313|EMBL:EEC12894.1};
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1] {ECO:0000313|EMBL:EEC12894.1, ECO:0000313|Proteomes:UP000001555}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC   {ECO:0000313|EMBL:EEC12894.1};
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ISCW020034-PA}
RP   IDENTIFICATION.
RC   STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW020034-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:60344, Rhea:RHEA-COMP:15554, Rhea:RHEA-COMP:15555,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.361;
CC         Evidence={ECO:0000256|ARBA:ARBA00000350};
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; ABJB011115007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS840716; EEC12894.1; -; Genomic_DNA.
DR   RefSeq; XP_002410343.1; XM_002410298.1.
DR   AlphaFoldDB; B7Q222; -.
DR   STRING; 6945.B7Q222; -.
DR   PaxDb; 6945-B7Q222; -.
DR   EnsemblMetazoa; ISCW020034-RA; ISCW020034-PA; ISCW020034.
DR   KEGG; isc:IscW_ISCW020034; -.
DR   VEuPathDB; VectorBase:ISCI020034; -.
DR   VEuPathDB; VectorBase:ISCP_022752; -.
DR   VEuPathDB; VectorBase:ISCW020034; -.
DR   HOGENOM; CLU_047978_2_1_1; -.
DR   InParanoid; B7Q222; -.
DR   OMA; KWCIDAT; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005700; C:polytene chromosome; IBA:GO_Central.
DR   GO; GO:0042799; F:histone H4K20 methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0140944; F:histone H4K20 monomethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0043516; P:regulation of DNA damage response, signal transduction by p53 class mediator; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd10528; SET_SETD8; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR016858; KMT5A-like.
DR   InterPro; IPR047266; KMT5A-like_SET.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR46167; N-LYSINE METHYLTRANSFERASE KMT5A; 1.
DR   PANTHER; PTHR46167:SF1; N-LYSINE METHYLTRANSFERASE KMT5A; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51571; SAM_MT43_PR_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:EEC12894.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EEC12894.1}.
FT   DOMAIN          48..169
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EEC12894.1"
SQ   SEQUENCE   184 AA;  21048 MW;  78FC638F8F602C76 CRC64;
     FRKGVVQCHS LTEYFPIRRS GRKTRSALAV SKERQKNVED AILNGDEDGF KVTEFDNKGR
     GVTTIRPLRS GDFVLEYAGE LIDHQEARLR EQLYAADKSV GCYMYYFSCR NKQYCVDATK
     ESGRLGRLVN HSKRGNLKTQ TCIIKGVPHL VLVAQRDIQP GEELLYDYGD RSKTSLQFHP
     WLAL
//