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B7Q1Y2 (B7Q1Y2_IXOSC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
ORF Names:IscW_ISCW010101 EMBL EEC12854.1
OrganismIxodes scapularis (Black-legged tick) (Deer tick)
Taxonomic identifier6945 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Acari › Parasitiformes › Ixodida › Ixodoidea › Ixodidae › Ixodinae › Ixodes

Protein attributes

Sequence length507 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding38 – 436NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding61 – 633NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding103 – 1053NADP By similarity PIRSR PIRSR000109-3
Region157 – 1593Substrate binding By similarity PIRSR PIRSR000109-2
Region214 – 2152Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site2111Proton acceptor By similarity PIRSR PIRSR000109-1
Active site2181Proton donor By similarity PIRSR PIRSR000109-1
Binding site1311NADP By similarity PIRSR PIRSR000109-3
Binding site1311Substrate By similarity PIRSR PIRSR000109-2
Binding site2191Substrate By similarity PIRSR PIRSR000109-2
Binding site2861Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site3131Substrate By similarity PIRSR PIRSR000109-2
Binding site4711Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4771Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Experimental info

Non-terminal residue11 EMBL EEC12854.1

Sequences

Sequence LengthMass (Da)Tools
B7Q1Y2 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 5BA52D5B23290D64

FASTA50755,126
        10         20         30         40         50         60 
LYAFHCGYLS LILVGSFSFP LNIAALLSLC RADIGLIGLA VMGQNLILNM NDHGHVVCAF 

        70         80         90        100        110        120 
NRTTEKVDEF LKKEAKGTKV IGAHSLEELV SKLKTPRRIV LLVKAGQAVD DFINKLTPLL 

       130        140        150        160        170        180 
TKGDILIDGG NSEYQDSERR CEALKAKGIL FVGSGVSGGE EGARYGPSLM PGGNKEAWPH 

       190        200        210        220        230        240 
IKDIFQGIAA KADGEPCCDW VGDGGSGHFV KMVHNGIEYG DMQLIGEAYH LIKDATGILH 

       250        260        270        280        290        300 
FEQVFDEWNK GVLDSFLIEI TSNILKYKDT DGEPLVTKIR DAAGQKGTGK WTAISALQHG 

       310        320        330        340        350        360 
IPVTLIGEAV FARCLSSLKD QRVEASKILK GPNGKYEGQA SDFVEHVRKA LYASKIVSYA 

       370        380        390        400        410        420 
QGFMLLRSAA QEYKWSLNYG AIALMWRGGC IIRSAFLGNI KAAFDKNPEL SCLLLDSFFV 

       430        440        450        460        470        480 
DAIQDCQASW RLVVASAAQL GIPVPAFSTA LAFYDGFRAE KLPANLIQAQ RDYFGAHTYE 

       490        500 
RLSEPGKFVH TNWTGTGGNV SSSSYNA

« Hide

References

[1]"Annotation of Ixodes scapularis."
Ixodes scapularis Genome Project Consortium
Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P., Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M., Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A. expand/collapse author list , Birren B., Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Wikel.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DS840333 Genomic DNA. Translation: EEC12854.1.
RefSeqXP_002410253.1. XM_002410209.1.
UniGeneIsc.4837.

3D structure databases

ProteinModelPortalB7Q1Y2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7Q1Y2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaISCW010101-RA; ISCW010101-PA; ISCW010101.
GeneID8034678.
KEGGisc:IscW_ISCW010101.
VectorBaseISCW010101. Ixodes scapularis.

Organism-specific databases

CTD8034678.

Phylogenomic databases

GeneTreeEMGT00050000006696.
OMASNYPDTN.
OrthoDBEOG4SN040.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB7Q1Y2_IXOSC
AccessionPrimary (citable) accession number: B7Q1Y2
Entry history
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info