ID   B7PUE8_IXOSC            Unreviewed;       428 AA.
AC   B7PUE8;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=(S)-3-amino-2-methylpropionate transaminase {ECO:0000256|ARBA:ARBA00030857};
DE            EC=2.6.1.19 {ECO:0000256|ARBA:ARBA00012912};
DE            EC=2.6.1.22 {ECO:0000256|ARBA:ARBA00012876};
DE   AltName: Full=GABA aminotransferase {ECO:0000256|ARBA:ARBA00031787};
DE   AltName: Full=Gamma-amino-N-butyrate transaminase {ECO:0000256|ARBA:ARBA00030204};
DE   AltName: Full=L-AIBAT {ECO:0000256|ARBA:ARBA00029760};
GN   Name=8031512 {ECO:0000313|EnsemblMetazoa:ISCW019639-PA};
GN   ORFNames=IscW_ISCW019639 {ECO:0000313|EMBL:EEC10220.1};
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1] {ECO:0000313|EMBL:EEC10220.1, ECO:0000313|Proteomes:UP000001555}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC   {ECO:0000313|EMBL:EEC10220.1};
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ISCW019639-PA}
RP   IDENTIFICATION.
RC   STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW019639-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|ARBA:ARBA00008954,
CC       ECO:0000256|RuleBase:RU003560}.
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DR   EMBL; ABJB010037531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS792129; EEC10220.1; -; Genomic_DNA.
DR   RefSeq; XP_002405970.1; XM_002405926.1.
DR   AlphaFoldDB; B7PUE8; -.
DR   STRING; 6945.B7PUE8; -.
DR   PaxDb; 6945-B7PUE8; -.
DR   EnsemblMetazoa; ISCW019639-RA; ISCW019639-PA; ISCW019639.
DR   GeneID; 8031512; -.
DR   KEGG; isc:IscW_ISCW019639; -.
DR   VEuPathDB; VectorBase:ISCI019639; -.
DR   VEuPathDB; VectorBase:ISCP_019242; -.
DR   VEuPathDB; VectorBase:ISCW019639; -.
DR   HOGENOM; CLU_016922_12_1_1; -.
DR   InParanoid; B7PUE8; -.
DR   OMA; KTQVCGI; -.
DR   OrthoDB; 177625at2759; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0047298; F:(S)-3-amino-2-methylpropionate transaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003867; F:4-aminobutyrate transaminase activity; IBA:GO_Central.
DR   GO; GO:0034386; F:4-aminobutyrate:2-oxoglutarate transaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR   GO; GO:0009450; P:gamma-aminobutyric acid catabolic process; IBA:GO_Central.
DR   CDD; cd00610; OAT_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR004631; 4NH2But_aminotransferase_euk.
DR   InterPro; IPR005814; Aminotrans_3.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR00699; GABAtrns_euk; 1.
DR   PANTHER; PTHR43206:SF1; 4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43206; AMINOTRANSFERASE; 1.
DR   Pfam; PF00202; Aminotran_3; 1.
DR   PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   1: Evidence at protein level;
KW   Aminotransferase {ECO:0000313|EMBL:EEC10220.1};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:B7PUE8};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|RuleBase:RU003560};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW   Transferase {ECO:0000313|EMBL:EEC10220.1}.
SQ   SEQUENCE   428 AA;  48142 MW;  E16EFC99D0D0EE8F CRC64;
     MFVDYEKSIG NYLYDVDGNA FLDIYTQISS LPLGYNHPAL VAAVKNPANV ATFVNRPAMG
     ILPPSDLVSR LKNALLSVAP SCLAEVQTMA CGSCSNENAY KAVFINYIAR ERDGRAPTEE
     ELHSCRFNKV PGSPRLSLLS FDGAFHGRTF GALSTTHSKA IHKLDVPSFD WPIAYFPQYR
     YPLEDFESDN RKEDDKSLAH VEELFHVYRK KGLPVAGLVV EPIQAEGGDR HASDDFFRRL
     LKLAKQSDVL FICDEVQTGC GPTGRFWAHQ HWGAEDSPDF VTFSKKMLTG GYFYKGHVRP
     KESYRIFNTW VGDPTKLLLV QEVLKVVNSE ELLRNVVETG DYMMKGLKEI GKRHPNSFFN
     VRGRGTFCAV DLPTEADRNK FVLAMHLKGV HCGGCGNNSF RIRPALTFQK KHADIMLDRV
     ERVLSDMF
//