B7PTS0 (B7PTS0_IXOSC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GMP reductase RuleBase RU003929
EC=1.7.1.7 RuleBase RU003929

Gene names

ORF Names:

IscW_ISCW019974 EMBL EEC09992.1

Organism

Ixodes scapularis (Black-legged tick) (Deer tick)

Taxonomic identifier

6945 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Acari › Parasitiformes › Ixodida › Ixodoidea › Ixodidae › Ixodinae › Ixodes

Protein attributes

Sequence length	365 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. RuleBase RU003929
Catalytic activity	Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. RuleBase RU003929
Sequence similarities	Belongs to the IMPDH/GMPR family. RuleBase RU003927

Ontologies

Keywords
Ligand	Metal-binding RuleBase RU003929 NADP RuleBase RU003929 Potassium RuleBase RU003929
Molecular function	Oxidoreductase RuleBase RU003927 EMBL EEC09992.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	GMP reductase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	365	1	EMBL EEC09992.1

Sequences

	Sequence		Length	Mass (Da)
	B7PTS0 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 133A9428A026E76E	FASTA	365	39,715
	10 20 30 40 50 60 MPHIDNDIKL DFKDVLLRPK RSTLKSRIEV DLNRSFKFRN SRASFDGVPI IAANMDTVGT 70 80 90 100 110 120 FEMAQVLAKN SLFTAIHKHY SVEQWKEFCS SNPSIVENVA VSSGSSQADY EKMKAILKEI 130 140 150 160 170 180 PQLRYICLDV ANGYSEVFVQ FVRAVRKEFP NHTIMAGNVV TGEMVEELLL SGADIIKVGI 190 200 210 220 230 240 GPGSVCTTRK KTGVGYPQLS AVIECADAAH GLDGHIISDG GCTCPGDVAK AFGAGADFVM 250 260 270 280 290 300 LGGMLAGHDQ SGGEVIEKDG QKYKMFYGMS SATAMEKYHG GVAEYRASEG KTVQVPYRGD 310 320 330 340 350 360 VQATILDVLG GLRSACTYTG AGRLKELPRR TTFIRVTQQL NEVSAKKLES CLLPHPCLRN LDQSC

References

[1]

"Annotation of Ixodes scapularis." Ixodes scapularis Genome Project Consortium Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P., Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M., Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A. , Birren B., Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Wikel.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS787900 Genomic DNA. Translation: EEC09992.1.
RefSeq	XP_002404837.1. XM_002404793.1.
3D structure databases
ProteinModelPortal	B7PTS0.
ModBase	Search...
Protein-protein interaction databases
STRING	B7PTS0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ISCW019974-RA; ISCW019974-PA; ISCW019974.
GeneID	8031240.
KEGG	isc:IscW_ISCW019974.
VectorBase	ISCW019974. Ixodes scapularis.
Organism-specific databases
CTD	8031240.
Phylogenomic databases
GeneTree	EMGT00050000017522.
OMA	FRNSKQM.
OrthoDB	EOG45TB3Q.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR005993. GMP_reduct1. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00364.
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF000235. GMP_reductase. 1 hit.
TIGRFAMs	TIGR01305. GMP_reduct_1. 1 hit.
PROSITE	PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B7PTS0_IXOSC

Accession

Primary (citable) accession number: B7PTS0

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	November 16, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)