ID   B7PNR1_IXOSC            Unreviewed;      2114 AA.
AC   B7PNR1;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EEC08233.1, ECO:0000313|EnsemblMetazoa:ISCW005314-PA};
GN   ORFNames=IscW_ISCW005314 {ECO:0000313|EMBL:EEC08233.1};
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1] {ECO:0000313|EMBL:EEC08233.1, ECO:0000313|Proteomes:UP000001555}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC   {ECO:0000313|EMBL:EEC08233.1};
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ISCW005314-PA}
RP   IDENTIFICATION.
RC   STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW005314-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ABJB010058956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010059122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010130717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010196320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010280050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010318996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010433357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010935157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB011067173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB011130795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS754365; EEC08233.1; -; Genomic_DNA.
DR   RefSeq; XP_002435403.1; XM_002435358.1.
DR   STRING; 6945.B7PNR1; -.
DR   PaxDb; 6945-B7PNR1; -.
DR   EnsemblMetazoa; ISCW005314-RA; ISCW005314-PA; ISCW005314.
DR   KEGG; isc:IscW_ISCW005314; -.
DR   VEuPathDB; VectorBase:ISCI005314; -.
DR   VEuPathDB; VectorBase:ISCP_022842; -.
DR   VEuPathDB; VectorBase:ISCW005314; -.
DR   HOGENOM; CLU_232194_0_0_1; -.
DR   InParanoid; B7PNR1; -.
DR   OMA; PANTEIC; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0016586; C:RSC-type complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0006368; P:transcription elongation by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd04717; BAH_polybromo; 1.
DR   CDD; cd15548; PHD_ASH1L; 1.
DR   Gene3D; 2.30.30.490; -; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR043151; BAH_sf.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR018359; Bromodomain_CS.
DR   InterPro; IPR043319; PHD_ASH1L.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR037382; Rsc/polybromo.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR16062:SF22; HISTONE-LYSINE N-METHYLTRANSFERASE ASH1L; 1.
DR   PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR   Pfam; PF01426; BAH; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF20826; PHD_5; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00439; BAH; 1.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SUPFAM; SSF47370; Bromodomain; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51038; BAH; 1.
DR   PROSITE; PS00633; BROMODOMAIN_1; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          1479..1495
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   DOMAIN          1673..1743
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   DOMAIN          1899..2029
FT                   /note="BAH"
FT                   /evidence="ECO:0000259|PROSITE:PS51038"
FT   REGION          1..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          305..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          505..666
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          692..720
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          766..1089
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1103..1175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1182..1201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1246..1402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1501..1550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1579..1620
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1886..1915
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..94
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..160
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..237
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        248..280
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..422
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..459
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        506..666
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        692..713
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        780..797
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        807..821
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        827..855
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        857..871
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        916..935
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        942..959
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        970..1000
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1025..1044
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1056..1077
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1138..1156
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1246..1267
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1268..1298
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1349..1363
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1502..1524
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1579..1598
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1886..1905
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2114 AA;  232327 MW;  708D13291AE67F16 CRC64;
     MEDVGGSATE DNICGGARNA SRSPQGAKVH LGTTPPEQPQ DPLKLRIAAR RVAKAQDGSP
     AGSAAAAADA AGSAAVRLRI KQRKSRRRRR SRSPPGKCGA ADGGGKPRCS CMGSRIGKVG
     SSSSSSDSES SCSVSDYSTC RTPRKADPCL PRREEPRRTP PLLSPTKLVP ASIADARLRD
     SADIAKGTEE GAKPSPVGTA LTNDGGAVEH PLPYLSVDAP ANVSPDSGIQ SCGESPQRIV
     GCQDDAPGFH GDEPHPYKSP HFALHDDLRP SDKTEPLKSG RTDGEGASCV DSAVQPLRVC
     ASQKVGFRND PSERTSPPLD IECKMADAEA AKELPSSPPR CASTTTAASP KTLPNIGSSA
     KDGFSDRTVD DRVDLTKVAD VVLPSPSERL RSKGAEKEAP KDASAVSPPR LRSRKEGEAP
     CKPTERLSGA KTRVKGASAP LSRSGRASRS AASKTSSRKS GRLECGDSEL HQLVQRVQDS
     ICTQFQESMG ASSDFEVGAD LCGGDCIEME EPRPKDEVTE VDEPKEMSKK TEHVSSKTVE
     EEERKERKEE TKAEEKPVPR KRGRPPRSDK TRRAVKVEAT TSRQRRRHAS KEDVVTSKAT
     TDRKVPPKEL DSKPDVNAIE SRYRKEPRKS TSTDCRVKSS SRKTEEISKE AETPHDSLPR
     EDGGDESVDI DALLHECSIE EQTHLLHMYQ RKMKKKRFVQ QPSRRNRRGG LRKSSSRACR
     ESESCASIDA LVEALSSAFI SKQTTVPKTD AVPSIFRIVK YLRPKRSSER PLRQSVSMAK
     TELRKTEKEE AKAAPAKKGK PKKQTQPSPA VPESSPELQT PPSGDRCLPL KKRHCLLSDE
     KSSTEEKEPK PPNASAERNH GKQTTAAPTE VPAKKTSEAA ETPCPPRSCE TPVLTKAAKK
     ALFPIVPSKP PCPEPKAPKK KKKARGKKQR PHPRTKRTSG NGNDDGRVPA SSTSVDEAIE
     SCVQKFADSA KSSEESRSRS RSRSPHAAEE ARRSDDSEAV TLVEDDSDPD NPLKKISLLK
     QKQQKLLKAV ERARRSKEKQ NEASPAGDDP AQTGKRHRKR KMRNRTGFVK VKRKRVAAQK
     APVAAAAAAS DYKFDLEEKD SCEDVSMKED DAAEDVGSVQ TGVHQPEVDE KAKVASKKSV
     KGRGRRKGRK KKIVCKPAKK MAIEKKAASP EPAVKASATE VELAKVPAPD PAPDSSPDLA
     KPAAAVVDTI AEAIEAVVAR AKKVASVPSA KGKVKAKVEA IAVAAAKRKE APQKEVVHPK
     KKAIKSKEAS APTSTPTLSA AASSDAASTS SAASSASGVA GGSKPPKKKC KLDSASHKAA
     SPINGGPPLP ENTPVVTVTK PSCGGGAQHG TRRRRRREHQ LPKKKYLKAG LYSSSFKEDG
     EPSKEESPPP EEKSGGLMPS PIHAGKYLRQ RRADFQLCYD IWWLHKHKQL LFSYDPVNNY
     KRIKSVNGVY RVGLFSLKDI PANTEICYDY NFHNFNNERQ QECKCGSDQC RGFIGGKSQR
     LNGQAKEKDK AKEGAKGTSS RSVRKRQRER LRHRRDGKPE GVTTVASSSA RLGPLQLKPL
     SHQQRCFVQK HRCFLLRNYD RAKRSPPKPL RDRGKHCQHQ AGPSPPAQHP QPPGEEEEGE
     AFRTQFTALN TSRSVRTRQL ARAQENTQLA RTARLAQVFR DICSSVLACK DDNGKVLSTP
     FVNLPSKRKC PDYFEKIHTP IDLNTIEKNI ITGEYKDLET FAADFNLLFD NAELYHKENV
     DLVSSLGKLR RCYEEAKYLV VPILEDILGE PVPSHFTTYS STNEKPAEED EEVIRCVCNI
     FKDEGLMIQC EKCFVWQHCD CMGVNGDIEN YLCELCNPRE VCLEIPLGPP VQNGGYQSFL
     TLLKGTLQVR QGDCVYLAKD KSPLKPLSQE VRSERSRRSA DAAGDPDEAE EAEPENSLDI
     FRVERLWKNE RQVLFNCCHS RVWGEKFLFG HHYLRPHETF HEPTRKFFHN EVLRIPLYEI
     VPLECVVGTC CVLDLATYCR GRPRGCAEKD VYVCECRVDK GARLFYKITK PKYPVCTKSY
     AFDVFETKLT PKRTYSPRSV PVVYQKRSRT RVAGFADTSS ADREVKKERL DKVVRRLAAS
     AATEKTSEIL EATR
//