B7P6J4 (B7P6J4_IXOSC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA topoisomerase 2 RuleBase RU000381
EC=5.99.1.3 RuleBase RU000381

Gene names

ORF Names:

IscW_ISCW024091 EMBL EEC02216.1

Organism

Ixodes scapularis (Black-legged tick) (Deer tick)

Taxonomic identifier

6945 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Acari › Parasitiformes › Ixodida › Ixodoidea › Ixodidae › Ixodinae › Ixodes

Protein attributes

Sequence length	538 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks By similarity. RuleBase RU000381
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. RuleBase RU000381
Subunit structure	Homodimer By similarity. RuleBase RU000381
Sequence similarities	Belongs to the type II topoisomerase family. RuleBase RU000380

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000380 DNA-binding RuleBase RU000381 Nucleotide-binding
Molecular function	Isomerase Topoisomerase RuleBase RU000380
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	538	1	EMBL EEC02216.1

Sequences

	Sequence		Length	Mass (Da)
	B7P6J4 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 135B0D4B4624DF95	FASTA	538	59,099
	10 20 30 40 50 60 MYTRTDNPLH IVQEVIDNAA DEALAGFART LTVTLLEDGG IQVEDDGRGI PVGLHPEENA 70 80 90 100 110 120 PVVELVFTRL HAGGKFDKLN GGAYAFSGGL HGVGVSVTNA LSRRLEVLVW RDGQANEIVF 130 140 150 160 170 180 ADGELEQPLT QTGTVGKRKT GTRVRVWPDP KYFDSAQIPL AQLTHILHSK AVLLEGVTVE 190 200 210 220 230 240 LVQQKTGQRQ QWCYEDGLRG YLQEEMDGVE LLVPLFEGRQ YAPQDDDNFS AGEGAHWVVA 250 260 270 280 290 300 WALDSNIVRE SYVNLIPTPA GGTHESGLRD GLYQAVRSFA ELHSLIPKGV KLQAEDVFAR 310 320 330 340 350 360 ASFVLSAKVL DPQFQGQIKE KLNSRDAVRL VSGYVRNALE LHLHANVDQG RKLAEVAVRQ 370 380 390 400 410 420 AQARTRSAQK VEKRKSSGVA VLPGKLTDCE SHDLESSELF LVEGDSAGGS AKMGRDKEFQ 430 440 450 460 470 480 AILPLRGKVL NAWEVDKDRL FANQEIHDIS VAIGVDPHDA QSEPDLSGLR YGRICILSDA 490 500 510 520 530 DVDGSHIQVL LLTLFFRHFP KLIEAGHVYV ARPPLFRVDV PAAGKRPARK IYCLDQGE

References

[1]

"Annotation of Ixodes scapularis." Ixodes scapularis Genome Project Consortium Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P., Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M., Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A. , Birren B., Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Wikel.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS646419 Genomic DNA. Translation: EEC02216.1.
RefSeq	XP_002408893.1. XM_002408849.1.
3D structure databases
ProteinModelPortal	B7P6J4.
ModBase	Search...
Protein-protein interaction databases
STRING	B7P6J4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ISCW024091-RA; ISCW024091-PA; ISCW024091.
GeneID	8025365.
KEGG	isc:IscW_ISCW024091.
VectorBase	ISCW024091. Ixodes scapularis.
Organism-specific databases
CTD	8025365.
Phylogenomic databases
GeneTree	EMGT00050000006469.
OMA	FKPARLM.
Family and domain databases
InterPro	IPR003594. ATPase-like_ATP-bd. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR001241. Topo_IIA. IPR013759. Topo_IIA_B/N_ab. IPR013506. Topo_IIA_bsu_dom2. IPR013760. Topo_IIA_cen. IPR018522. TopoIIA_CS. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.40.50.670. Topo_IIA_B/N_ab. 1 hit.
Pfam	PF00204. DNA_gyraseB. 1 hit. PF02518. HATPase_c. 1 hit. [Graphical view]
PRINTS	PR00418. TPI2FAMILY.
SMART	SM00387. HATPase_c. 1 hit. SM00433. TOP2c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF56719. Topo_IIA_cen. 1 hit.
PROSITE	PS00177. TOPOISOMERASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B7P6J4_IXOSC

Accession

Primary (citable) accession number: B7P6J4

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)