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B7P4Y1 (B7P4Y1_IXOSC) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase RuleBase RU000548
EC=3.3.1.1 RuleBase RU000548
Gene names
ORF Names:IscW_ISCW015944 EMBL EEC01653.1
OrganismIxodes scapularis (Black-legged tick) (Deer tick)
Taxonomic identifier6945 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Acari › Parasitiformes › Ixodida › Ixodoidea › Ixodidae › Ixodinae › Ixodes

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. RuleBase RU000548

Cofactor

NAD By similarity. RuleBase RU000548

Pathway

Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. RuleBase RU000548

Sequence similarities

Belongs to the adenosylhomocysteinase family. RuleBase RU004166

Ontologies

Keywords
   Biological processOne-carbon metabolism RuleBase RU000548
   LigandNAD RuleBase RU000548
   Molecular functionHydrolase RuleBase RU000548 EMBL EEC01653.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Binding site581Substrate By similarity PIRSR PIRSR001109-1
Binding site1331Substrate By similarity PIRSR PIRSR001109-1
Binding site1491Substrate By similarity PIRSR PIRSR001109-1
Binding site1791Substrate By similarity PIRSR PIRSR001109-1
Binding site1831Substrate By similarity PIRSR PIRSR001109-1

Sequences

Sequence LengthMass (Da)Tools
B7P4Y1 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 5E0B9F9832930B50

FASTA42546,954
        10         20         30         40         50         60 
MSASKPPYKI ADIGLAEFGR KELVMAENEM PGLMALRRKY GPSKPLKGAR IAGCLHMTIQ 

        70         80         90        100        110        120 
TAVLIETLIE LGAEVQWSSC NIFSTQDHAA AAIAKRGVPV YAWKGETEEE YIWCIEQTLV 

       130        140        150        160        170        180 
FKDGQPLNMI LDDGGDLTNL VLTKYPQYET TTGVHHLYKM KKEGKLTIPA INVNDSVTKS 

       190        200        210        220        230        240 
KFDNLYGCRE SLADGIKRAT DVMIAGKVAC VAGFGDVGKG CAQSLRGFGA RVLVTEIDPI 

       250        260        270        280        290        300 
NALQAAMEGY EVTTMDDAAS RASLFVTATG CRDILRGEHF MKMRNDSIVC NIGHFDIEID 

       310        320        330        340        350        360 
VKWLDQNAVE KVEVKPQVDR YKLTNGNHII CLAQGRLVNL GCAMGHPSFV MSTSFTNQVL 

       370        380        390        400        410        420 
AQIELWTKSD QYAVDVHFLP KKLDEEVAAL HLDHLGVKMT KLTNEQSSYL GIPSEGPFKP 


NHYRY

« Hide

References

[1]"Annotation of Ixodes scapularis."
Ixodes scapularis Genome Project Consortium
Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P., Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M., Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A. expand/collapse author list , Birren B., Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Wikel.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DS637651 Genomic DNA. Translation: EEC01653.1.
RefSeqXP_002406593.1. XM_002406549.1.
UniGeneIsc.2835.

3D structure databases

ProteinModelPortalB7P4Y1.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7P4Y1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaISCW015944-RA; ISCW015944-PA; ISCW015944.
GeneID8024680.
KEGGisc:IscW_ISCW015944.
VectorBaseISCW015944. Ixodes scapularis.

Organism-specific databases

CTD8024680.

Phylogenomic databases

GeneTreeEMGT00050000015433.
OMAELFTKTE.
OrthoDBEOG45DV4T.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB7P4Y1_IXOSC
AccessionPrimary (citable) accession number: B7P4Y1
Entry history
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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