B7NTL2 (FRDD_ECO7I) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fumarate reductase subunit D

Alternative name(s):
Fumarate reductase 13 kDa hydrophobic protein

Gene names

Name:	frdD
Ordered Locus Names:	ECIAI39_4618

Organism

Escherichia coli O7:K1 (strain IAI39 / ExPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

585057 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane By similarity. HAMAP-Rule MF_00709
Subunit structure	Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD) By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00709.
Sequence similarities	Belongs to the FrdD family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fumarate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	Fumarate reductase subunit D HAMAP-Rule MF_00709		PRO_1000132398
Regions
	Transmembrane	26 – 46	21	Helical; Potential
	Transmembrane	55 – 75	21	Helical; Potential
	Transmembrane	99 – 119	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B7NTL2 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: E9D119342B1D5357	FASTA	119	13,107
	10 20 30 40 50 60 MINPNPKRSD EPVFWGLFGA GGMWSAIIAP VMILLVGILL PLGLFPGDAL SYERVLAFAQ 70 80 90 100 110 SFIGRVFLFL MIVLPLWCGL HRMHHAMHDL KIHVPAGKWV FYGLAAILTV VTLIGVVTI

References

[1]

"Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths." Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P., Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H., Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E. , Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C., Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S., Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J., Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E. PLoS Genet. 5:E1000344-E1000344(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IAI39 / ExPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU928164 Genomic DNA. Translation: CAR20718.1.
RefSeq	YP_002410482.1. NC_011750.1.
3D structure databases
ProteinModelPortal	B7NTL2.
SMR	B7NTL2. Positions 1-119.
ModBase	Search...
Protein-protein interaction databases
STRING	585057.ECIAI39_4618.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAR20718; CAR20718; ECIAI39_4618.
GeneID	7150729.
KEGG	ect:ECIAI39_4618.
PATRIC	18338215. VBIEscCol51957_4767.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3080.
HOGENOM	HOG000281495.
KO	K00247.
OMA	GKIACYA.
ProtClustDB	PRK05470.
Enzyme and pathway databases
BioCyc	ECOL585057:GJ8I-4777-MONOMER.
Family and domain databases
HAMAP	MF_00709. Fumarate_red_D.
InterPro	IPR003418. Fumarate_red_D. [Graphical view]
Pfam	PF02313. Fumarate_red_D. 1 hit. [Graphical view]
PIRSF	PIRSF000179. FrdD. 1 hit.
ProDom	PD015693. Fumarate_red_D. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

FRDD_ECO7I

Accession

Primary (citable) accession number: B7NTL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program