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B7NPB4

- LLDD_ECO7I

UniProt

B7NPB4 - LLDD_ECO7I

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Protein

L-lactate dehydrogenase

Gene
lldD, ECIAI39_4126
Organism
Escherichia coli O7:K1 (strain IAI39 / ExPEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain By similarity.

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.

Cofactori

FMN By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei24 – 241Substrate Reviewed prediction
Binding sitei106 – 1061FMN By similarity
Binding sitei127 – 1271FMN By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei155 – 1551FMN By similarity
Binding sitei164 – 1641Substrate By similarity
Binding sitei251 – 2511FMN By similarity
Active sitei275 – 2751Proton acceptor By similarity
Binding sitei278 – 2781Substrate Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi306 – 33025FMN By similarityAdd
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. L-lactate dehydrogenase (cytochrome) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciECOL585057:GJ8I-4273-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase (EC:1.1.-.-)
Gene namesi
Name:lldD
Ordered Locus Names:ECIAI39_4126
OrganismiEscherichia coli O7:K1 (strain IAI39 / ExPEC)
Taxonomic identifieri585057 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000749: Chromosome

Subcellular locationi

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396L-lactate dehydrogenasePRO_0000383428Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi585057.ECIAI39_4126.

Structurei

3D structure databases

ProteinModelPortaliB7NPB4.
SMRiB7NPB4. Positions 3-377.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 380380FMN hydroxy acid dehydrogenaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1304.
HOGENOMiHOG000217464.
KOiK00101.
OMAiDCTLLGR.
OrthoDBiEOG6HMXBG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01559. L_lact_dehydr.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7NPB4-1 [UniParc]FASTAAdd to Basket

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MIISAASDYR AAAQRILPPF LFHYMDGGAY SEYTLRRNVE DLSEVALRQR    50
ILKNMSDLSL ETTLFNEKLS MPVALGPVGL CGMYARRGEV QAAKAADAHG 100
IPFTLSTVSV CPIEEVAPAI KRPMWFQLYV LRDRGFMRNA LERAKAAGCS 150
TLVFTVDMPT PGARYRDAHS GMSGPNAAMR RYLQAVTHPQ WAWDVGLNGR 200
PHDLGNISAY LGKPTGLEDY IGWLGNNFDP SISWKDLEWI RDFWDGPMVI 250
KGILDPEDAR DAVRFGADGI VVSNHGGRQL DGVLSSARAL PAIADAVKGD 300
IAILADSGIR NGLDVVRMIA LGADTVLLGR AFLYALATAG QAGVANLLNL 350
IEKEMKVAMT LTGAKSISEI TQDSLVQGLG KELPAALAPM AKGNAA 396
Length:396
Mass (Da):42,714
Last modified:February 10, 2009 - v1
Checksum:iED12F511FF74A181
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928164 Genomic DNA. Translation: CAR20234.1.
RefSeqiYP_002410003.1. NC_011750.1.

Genome annotation databases

EnsemblBacteriaiCAR20234; CAR20234; ECIAI39_4126.
GeneIDi7151948.
KEGGiect:ECIAI39_4126.
PATRICi18337205. VBIEscCol51957_4276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928164 Genomic DNA. Translation: CAR20234.1 .
RefSeqi YP_002410003.1. NC_011750.1.

3D structure databases

ProteinModelPortali B7NPB4.
SMRi B7NPB4. Positions 3-377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 585057.ECIAI39_4126.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR20234 ; CAR20234 ; ECIAI39_4126 .
GeneIDi 7151948.
KEGGi ect:ECIAI39_4126.
PATRICi 18337205. VBIEscCol51957_4276.

Phylogenomic databases

eggNOGi COG1304.
HOGENOMi HOG000217464.
KOi K00101.
OMAi DCTLLGR.
OrthoDBi EOG6HMXBG.

Enzyme and pathway databases

BioCyci ECOL585057:GJ8I-4273-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01559. L_lact_dehydr.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_bac.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IAI39 / ExPEC.

Entry informationi

Entry nameiLLDD_ECO7I
AccessioniPrimary (citable) accession number: B7NPB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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