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B7NP65

- XYLA_ECO7I

UniProt

B7NP65 - XYLA_ECO7I

Protein

Xylose isomerase

Gene

xylA

Organism
Escherichia coli O7:K1 (strain IAI39 / ExPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.UniRule annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei101 – 1011UniRule annotation
    Active sitei104 – 1041UniRule annotation
    Metal bindingi232 – 2321Magnesium 1UniRule annotation
    Metal bindingi268 – 2681Magnesium 1UniRule annotation
    Metal bindingi268 – 2681Magnesium 2UniRule annotation
    Metal bindingi271 – 2711Magnesium 2UniRule annotation
    Metal bindingi296 – 2961Magnesium 1UniRule annotation
    Metal bindingi307 – 3071Magnesium 2UniRule annotation
    Metal bindingi309 – 3091Magnesium 2UniRule annotation
    Metal bindingi339 – 3391Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shunt, Xylose metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciECOL585057:GJ8I-4224-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
    Gene namesi
    Name:xylAUniRule annotation
    Ordered Locus Names:ECIAI39_4077
    OrganismiEscherichia coli O7:K1 (strain IAI39 / ExPEC)
    Taxonomic identifieri585057 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000749: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 440440Xylose isomerasePRO_1000200295Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi585057.ECIAI39_4077.

    Structurei

    3D structure databases

    ProteinModelPortaliB7NP65.
    SMRiB7NP65. Positions 2-439.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2115.
    HOGENOMiHOG000252293.
    KOiK01805.
    OrthoDBiEOG62NX4R.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7NP65-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQAYFDQLDR VRYEGSKSSN PLAFRHYNPD ELVLGKRMEE HLRFAACYWH    50
    TFCWNGADMF GVGAFNRPWQ QPGEALALAK RKADVAFEFF HKLHVPFYCF 100
    HDVDVSPEGA SLKEYINNFA QMVDVLAGKQ EESGVKLLWG TANCFTNPRY 150
    GAGAATNPDP EVFSWAATQV VTAMEATHKL GGENYVLWGG REGYETLLNT 200
    DLRQEREQLG RFMQMVVEHK HKIGFQGTLL IEPKPQEPTK HQYDYDAATV 250
    YGFLKQFGLE KEIKLNIEAN HATLAGHSFH HEIATAIALG LFGSVDANRG 300
    DAQLGWDTDQ FPNSVEENAL VMYEILKAGG FTTGGLNFDA KVRRQSTDKY 350
    DLFYGHIGAM DTMALALKIA ARMIEDGELD KRIAQRYSGW NSELGQQILK 400
    GQMSLADLAK YAQEHNLSPV HQSGRQEQLE NLVNHYLFDK 440
    Length:440
    Mass (Da):49,719
    Last modified:March 24, 2009 - v1
    Checksum:i6E21039B6EC0561F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928164 Genomic DNA. Translation: CAR20185.1.
    RefSeqiYP_002409960.1. NC_011750.1.

    Genome annotation databases

    EnsemblBacteriaiCAR20185; CAR20185; ECIAI39_4077.
    GeneIDi7153186.
    KEGGiect:ECIAI39_4077.
    PATRICi18337109. VBIEscCol51957_4228.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU928164 Genomic DNA. Translation: CAR20185.1 .
    RefSeqi YP_002409960.1. NC_011750.1.

    3D structure databases

    ProteinModelPortali B7NP65.
    SMRi B7NP65. Positions 2-439.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 585057.ECIAI39_4077.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR20185 ; CAR20185 ; ECIAI39_4077 .
    GeneIDi 7153186.
    KEGGi ect:ECIAI39_4077.
    PATRICi 18337109. VBIEscCol51957_4228.

    Phylogenomic databases

    eggNOGi COG2115.
    HOGENOMi HOG000252293.
    KOi K01805.
    OrthoDBi EOG62NX4R.

    Enzyme and pathway databases

    BioCyci ECOL585057:GJ8I-4224-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IAI39 / ExPEC.

    Entry informationi

    Entry nameiXYLA_ECO7I
    AccessioniPrimary (citable) accession number: B7NP65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3