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B7NP65

- XYLA_ECO7I

UniProt

B7NP65 - XYLA_ECO7I

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Protein

Xylose isomerase

Gene

xylA

Organism
Escherichia coli O7:K1 (strain IAI39 / ExPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotation

Cofactori

Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011UniRule annotation
Active sitei104 – 1041UniRule annotation
Metal bindingi232 – 2321Magnesium 1UniRule annotation
Metal bindingi268 – 2681Magnesium 1UniRule annotation
Metal bindingi268 – 2681Magnesium 2UniRule annotation
Metal bindingi271 – 2711Magnesium 2UniRule annotation
Metal bindingi296 – 2961Magnesium 1UniRule annotation
Metal bindingi307 – 3071Magnesium 2UniRule annotation
Metal bindingi309 – 3091Magnesium 2UniRule annotation
Metal bindingi339 – 3391Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciECOL585057:GJ8I-4224-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:ECIAI39_4077
OrganismiEscherichia coli O7:K1 (strain IAI39 / ExPEC)
Taxonomic identifieri585057 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000749: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Xylose isomerasePRO_1000200295Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi585057.ECIAI39_4077.

Structurei

3D structure databases

ProteinModelPortaliB7NP65.
SMRiB7NP65. Positions 2-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7NP65-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQAYFDQLDR VRYEGSKSSN PLAFRHYNPD ELVLGKRMEE HLRFAACYWH
60 70 80 90 100
TFCWNGADMF GVGAFNRPWQ QPGEALALAK RKADVAFEFF HKLHVPFYCF
110 120 130 140 150
HDVDVSPEGA SLKEYINNFA QMVDVLAGKQ EESGVKLLWG TANCFTNPRY
160 170 180 190 200
GAGAATNPDP EVFSWAATQV VTAMEATHKL GGENYVLWGG REGYETLLNT
210 220 230 240 250
DLRQEREQLG RFMQMVVEHK HKIGFQGTLL IEPKPQEPTK HQYDYDAATV
260 270 280 290 300
YGFLKQFGLE KEIKLNIEAN HATLAGHSFH HEIATAIALG LFGSVDANRG
310 320 330 340 350
DAQLGWDTDQ FPNSVEENAL VMYEILKAGG FTTGGLNFDA KVRRQSTDKY
360 370 380 390 400
DLFYGHIGAM DTMALALKIA ARMIEDGELD KRIAQRYSGW NSELGQQILK
410 420 430 440
GQMSLADLAK YAQEHNLSPV HQSGRQEQLE NLVNHYLFDK
Length:440
Mass (Da):49,719
Last modified:March 24, 2009 - v1
Checksum:i6E21039B6EC0561F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928164 Genomic DNA. Translation: CAR20185.1.
RefSeqiYP_002409960.1. NC_011750.1.

Genome annotation databases

EnsemblBacteriaiCAR20185; CAR20185; ECIAI39_4077.
GeneIDi7153186.
KEGGiect:ECIAI39_4077.
PATRICi18337109. VBIEscCol51957_4228.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU928164 Genomic DNA. Translation: CAR20185.1 .
RefSeqi YP_002409960.1. NC_011750.1.

3D structure databases

ProteinModelPortali B7NP65.
SMRi B7NP65. Positions 2-439.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 585057.ECIAI39_4077.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR20185 ; CAR20185 ; ECIAI39_4077 .
GeneIDi 7153186.
KEGGi ect:ECIAI39_4077.
PATRICi 18337109. VBIEscCol51957_4228.

Phylogenomic databases

eggNOGi COG2115.
HOGENOMi HOG000252293.
KOi K01805.
OrthoDBi EOG62NX4R.

Enzyme and pathway databases

BioCyci ECOL585057:GJ8I-4224-MONOMER.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IAI39 / ExPEC.

Entry informationi

Entry nameiXYLA_ECO7I
AccessioniPrimary (citable) accession number: B7NP65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3