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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Escherichia coli O7:K1 (strain IAI39 / ExPEC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciECOL585057:G1GIC-767-MONOMER
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:ECIAI39_0735
OrganismiEscherichia coli O7:K1 (strain IAI39 / ExPEC)
Taxonomic identifieri585057 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000749 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001481521 – 3316-phosphogluconolactonaseAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287N6-acetyllysineUniRule annotation1

Keywords - PTMi

Acetylation

Structurei

3D structure databases

ProteinModelPortaliB7NNI9
SMRiB7NNI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000257418
KOiK07404
OMAiEGNWPRD

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
SUPFAMiSSF50974 SSF50974, 1 hit

Sequencei

Sequence statusi: Complete.

B7NNI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQTVYIASP ESQQIHVWNL NHEGVLTLTQ VVDVPGQVQP MVVSPDKRYL
60 70 80 90 100
YVGVRPEFRV LAYRIAPDDG ALTFAAESAL PGSPTHISTD HHGQFVFVGS
110 120 130 140 150
YNAGNVSVTR LEDGLPVGVV DVVEGLDGCH SANISPDNRT LWVPALKQDR
160 170 180 190 200
ICLFTVSDDG HLVAQEPAEV TTVEGAGPRH MVFHPNEQYA YCVNELNSSV
210 220 230 240 250
DVWELKDPHG NIECVQTLDM MPENFSDTRW AADIHITPDG RHLYACDRTA
260 270 280 290 300
SLITVFSVSE DGSVLSKEGF QPTETQQRGF NVDHSGKYLI AAGQKSHHIS
310 320 330
VYEIVGEQGL LHEKGRYAVG QGPMWVVVNA H
Length:331
Mass (Da):36,390
Last modified:February 10, 2009 - v1
Checksum:i8135EDEBBDB0C89C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928164 Genomic DNA Translation: CAR16872.1
RefSeqiWP_000815454.1, NC_011750.1
YP_002406761.1, NC_011750.1

Genome annotation databases

EnsemblBacteriaiCAR16872; CAR16872; ECIAI39_0735
GeneIDi7153340
KEGGiect:ECIAI39_0735
PATRICifig|585057.6.peg.778

Similar proteinsi

Entry informationi

Entry namei6PGL_ECO7I
AccessioniPrimary (citable) accession number: B7NNI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: March 28, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health