Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Escherichia coli O7:K1 (strain IAI39 / ExPEC)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:ECIAI39_0090
OrganismiEscherichia coli O7:K1 (strain IAI39 / ExPEC)
Taxonomic identifieri585057 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000749 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25PeriplasmicUniRule annotationAdd BLAST25
Transmembranei26 – 46HelicalUniRule annotationAdd BLAST21
Topological domaini47 – 71CytoplasmicUniRule annotationAdd BLAST25
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Topological domaini93PeriplasmicUniRule annotation1
Transmembranei94 – 114HelicalUniRule annotationAdd BLAST21
Topological domaini115 – 131CytoplasmicUniRule annotationAdd BLAST17
Transmembranei132 – 152HelicalUniRule annotationAdd BLAST21
Topological domaini153 – 167PeriplasmicUniRule annotationAdd BLAST15
Transmembranei168 – 188HelicalUniRule annotationAdd BLAST21
Topological domaini189 – 198CytoplasmicUniRule annotation10
Transmembranei199 – 219HelicalUniRule annotationAdd BLAST21
Topological domaini220 – 235PeriplasmicUniRule annotationAdd BLAST16
Transmembranei236 – 256HelicalUniRule annotationAdd BLAST21
Topological domaini257 – 262CytoplasmicUniRule annotation6
Transmembranei263 – 283HelicalUniRule annotationAdd BLAST21
Topological domaini284 – 287PeriplasmicUniRule annotation4
Transmembranei288 – 308HelicalUniRule annotationAdd BLAST21
Topological domaini309 – 337CytoplasmicUniRule annotationAdd BLAST29
Transmembranei338 – 358HelicalUniRule annotationAdd BLAST21
Topological domaini359 – 360PeriplasmicUniRule annotation2

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001165131 – 360Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST360

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B7NHJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVWLAEHLV KYYSGFNVFS YLTFRAIVSL LTALFISLWM GPRMIAHLQK
60 70 80 90 100
LSFGQVVRND GPESHFSKRG TPTMGGIMIL TAIVISVLLW AYPSNPYVWC
110 120 130 140 150
VLVVLVGYGI IGFVDDYRKV VRKDTKGLIA RWKYFWMSVI ALGVAFALYL
160 170 180 190 200
AGKDTPATQL VVPFFKDVMP QLGLFYILLA YFVIVGTGNA VNLTDGLDGL
210 220 230 240 250
AIMPTVFVAG GFALVAWATG NMNFASYLHI PYLRHAGELV IVCTAIVGAG
260 270 280 290 300
LGFLWFNTYP AQVFMGDVGS LALGGALGII AVLLRQEFLL VIMGGVFVVE
310 320 330 340 350
TLSVILQVGS FKLRGQRIFR MAPIHHHYEL KGWPEPRVIV RFWIISLMLV
360
LIGLATLKVR
Length:360
Mass (Da):39,889
Last modified:March 24, 2009 - v1
Checksum:iF3550D593CD63B3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928164 Genomic DNA. Translation: CAR16231.1.
RefSeqiWP_000964122.1. NC_011750.1.
YP_002406139.1. NC_011750.1.

Genome annotation databases

EnsemblBacteriaiCAR16231; CAR16231; ECIAI39_0090.
GeneIDi7152150.
KEGGiect:ECIAI39_0090.
PATRICifig|585057.6.peg.99.

Similar proteinsi

Entry informationi

Entry nameiMRAY_ECO7I
AccessioniPrimary (citable) accession number: B7NHJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 24, 2009
Last modified: June 7, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families