B7NH38 (RSMC_ECOLU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase C
EC=2.1.1.172

Alternative name(s):
16S rRNA m2G1207 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase RsmC

Gene names

Name:	rsmC
Ordered Locus Names:	ECUMN_4994

Organism

Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

585056 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle By similarity. HAMAP-Rule MF_01862
Catalytic activity	S-adenosyl-L-methionine + guanine(1207) in 16S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(1207) in 16S rRNA. HAMAP-Rule MF_01862
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_01862.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmC family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	16S rRNA (guanine(1207)-N(2))-methyltransferase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Ribosomal RNA small subunit methyltransferase C HAMAP-Rule MF_01862		PRO_0000369707

Sequences

	Sequence		Length	Mass (Da)
	B7NH38 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: C38DCB406131DDC8	FASTA	343	37,640
	10 20 30 40 50 60 MSAFTPASEV LLRHSDDFEQ SRILFAGDLQ DDLPARLDTA ASRAHTQQFH HWQVLSRQMG 70 80 90 100 110 120 DNARFSLVAT ADDVADCNTL IYYWPKNKPE AQFQLMNLLS LLPVGTDIFV VGENRSGVRS 130 140 150 160 170 180 AEQMLADYAP LNKVDSARRC GLYFGRLEKQ PEFDADKFWG EYSVDGLTVK TLPGVFSRDG 190 200 210 220 230 240 LDVGSQLLLS TLTPHTKGKV LDVGCGAGVL SVAFARHSPK IRLTLCDVSA PAVEASRATL 250 260 270 280 290 300 AANGVEGEVF ASNVFSEVKG RFDMIISNPP FHDGMQTSLD AAQTLIRGAV RHLNSGGELR 310 320 330 340 IVANAFLPYP DVLDETFGFH EVIAQTGRFK VYRAIMTRQA KKG

References

[1]

"Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths." Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P., Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H., Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E. , Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C., Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S., Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J., Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E. PLoS Genet. 5:E1000344-E1000344(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UMN026 / ExPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU928163 Genomic DNA. Translation: CAR16103.1.
RefSeq	YP_002415567.1. NC_011751.1.
3D structure databases
ProteinModelPortal	B7NH38.
SMR	B7NH38. Positions 3-336.
ModBase	Search...
Protein-protein interaction databases
STRING	585056.ECUMN_4994.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAR16103; CAR16103; ECUMN_4994.
GeneID	7155612.
KEGG	eum:ECUMN_4994.
PATRIC	18449353. VBIEscCol32010_5157.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2813.
HOGENOM	HOG000218308.
KO	K00564.
OMA	RHCQLWQ.
ProtClustDB	PRK09489.
Family and domain databases
HAMAP	MF_01862. 16SrRNA_methyltr_C.
InterPro	IPR002052. DNA_methylase_N6_adenine_CS. IPR013675. Mtase_sm_N. IPR023543. rRNA_ssu_MeTfrase_C. IPR007848. Small_mtfrase_dom. [Graphical view]
Pfam	PF05175. MTS. 1 hit. PF08468. MTS_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RSMC_ECOLU

Accession

Primary (citable) accession number: B7NH38

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program