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Protein

Chorismate pyruvate-lyase

Gene

ubiC

Organism
Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.UniRule annotation

Catalytic activityi

Chorismate = 4-hydroxybenzoate + pyruvate.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35Substrate; via amide nitrogenUniRule annotation1
Binding sitei77SubstrateUniRule annotation1
Binding sitei115Substrate; via amide nitrogenUniRule annotation1
Binding sitei156SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processUbiquinone biosynthesis
LigandPyruvate

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate pyruvate-lyaseUniRule annotation (EC:4.1.3.40UniRule annotation)
Short name:
CLUniRule annotation
Short name:
CPLUniRule annotation
Gene namesi
Name:ubiCUniRule annotation
Ordered Locus Names:ECUMN_4573
OrganismiEscherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
Taxonomic identifieri585056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000007097 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001865251 – 165Chorismate pyruvate-lyaseAdd BLAST165

Proteomic databases

PRIDEiB7NFY3

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7NFY3
SMRiB7NFY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000137785
KOiK03181
OMAiELWGRRS

Family and domain databases

Gene3Di3.40.1410.10, 1 hit
HAMAPiMF_01632 UbiC, 1 hit
InterProiView protein in InterPro
IPR007440 Chorismate--pyruvate_lyase
IPR028978 Chorismate_lyase_/UTRA_dom_sf
PANTHERiPTHR38683 PTHR38683, 1 hit
PfamiView protein in Pfam
PF04345 Chor_lyase, 1 hit
SUPFAMiSSF64288 SSF64288, 1 hit

Sequencei

Sequence statusi: Complete.

B7NFY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHPALTQLR ALRYFKEIPA LDTQLLDWLL LEDSMTKRFE QQGKTVSVTM
60 70 80 90 100
IREGFVEQNE IPEELPLLPK ESRYWLREIL LCADGEPWLA GRTVVPVSTL
110 120 130 140 150
SGPELALQKL GKTPLGRYLF TSSTLTRDFI EIGRDAGLWG RRSRLRLSGK
160
PLLLTELFLP ASPLY
Length:165
Mass (Da):18,825
Last modified:February 10, 2009 - v1
Checksum:i5EE75825BE0E1B96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928163 Genomic DNA Translation: CAR15690.1
RefSeqiWP_001305723.1, NC_011751.1
YP_002415180.1, NC_011751.1

Genome annotation databases

EnsemblBacteriaiCAR15690; CAR15690; ECUMN_4573
GeneIDi7159335
KEGGieum:ECUMN_4573
PATRICifig|585056.7.peg.4736

Similar proteinsi

Entry informationi

Entry nameiUBIC_ECOLU
AccessioniPrimary (citable) accession number: B7NFY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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