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Protein

Glutathione-regulated potassium-efflux system ancillary protein KefG

Gene

kefG

Organism
Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.UniRule annotation

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione-regulated potassium-efflux system ancillary protein KefGUniRule annotation
Alternative name(s):
Putative quinone oxidoreductase KefGUniRule annotation (EC:1.6.5.2UniRule annotation)
Gene namesi
Name:kefGUniRule annotation
Ordered Locus Names:ECUMN_3812
OrganismiEscherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
Taxonomic identifieri585056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000007097 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001455761 – 184Glutathione-regulated potassium-efflux system ancillary protein KefGAdd BLAST184

Interactioni

Subunit structurei

Interacts with KefB.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7NDW0.
SMRiB7NDW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000149972.
KOiK11748.
OMAiRYPMSDI.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01415. K_H_efflux_KefG. 1 hit.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_dom.
IPR023947. K_H_efflux_KefG.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.

Sequencei

Sequence statusi: Complete.

B7NDW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSQPAKVLL LYAHPESQDS VANRVLLKPA TQLSNVTVHD LYAHYPDFFI
60 70 80 90 100
DIPREQALLR EHEVIVFQHP LYTYSCPALL KEWLDRVLSR GFASGPGGNQ
110 120 130 140 150
LAGKYWRSVI TTGEPESAYR YDALNRYPMS DVLRPFELAA GMCRMHWLSP
160 170 180
IIIYWARRQS AQELASHARA YGDWLANPLS PGGR
Length:184
Mass (Da):20,958
Last modified:March 24, 2009 - v1
Checksum:iF3B1123F7378EAB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928163 Genomic DNA. Translation: CAR14960.1.
RefSeqiWP_000987657.1. NC_011751.1.
YP_002414465.1. NC_011751.1.

Genome annotation databases

EnsemblBacteriaiCAR14960; CAR14960; ECUMN_3812.
GeneIDi7156903.
KEGGieum:ECUMN_3812.
PATRICi18446935. VBIEscCol32010_3986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928163 Genomic DNA. Translation: CAR14960.1.
RefSeqiWP_000987657.1. NC_011751.1.
YP_002414465.1. NC_011751.1.

3D structure databases

ProteinModelPortaliB7NDW0.
SMRiB7NDW0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR14960; CAR14960; ECUMN_3812.
GeneIDi7156903.
KEGGieum:ECUMN_3812.
PATRICi18446935. VBIEscCol32010_3986.

Phylogenomic databases

HOGENOMiHOG000149972.
KOiK11748.
OMAiRYPMSDI.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01415. K_H_efflux_KefG. 1 hit.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_dom.
IPR023947. K_H_efflux_KefG.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKEFG_ECOLU
AccessioniPrimary (citable) accession number: B7NDW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 24, 2009
Last modified: November 2, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.