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Protein

2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase

Gene

citG

Organism
Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = 2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthaseUniRule annotation (EC:2.4.2.52UniRule annotation)
Short name:
2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthaseUniRule annotation
Gene namesi
Name:citGUniRule annotation
Ordered Locus Names:ECUMN_0706
OrganismiEscherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
Taxonomic identifieri585056 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000007097 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2922922-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthasePRO_1000123222Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB7N9L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CitG/MdcB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000258582.
KOiK05966.
OMAiIHRGGIK.
OrthoDBiEOG6WHNRS.

Family and domain databases

HAMAPiMF_00397. CitG.
InterProiIPR002736. CitG.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03125. citrate_citG. 1 hit.

Sequencei

Sequence statusi: Complete.

B7N9L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMPATSTKT TKLATSLIDE YALLGWRAML TEVNLSPKPG LVDRINCGAH
60 70 80 90 100
KDMALEDFHR SALAIQGWLP RFIEFGACSA EMAPEAVLHG LRPIGMACEG
110 120 130 140 150
DMFRATAGVN THKGSIFSLG LLCAAIGRLL QLNQSLTPTT VCSTAASFCR
160 170 180 190 200
GLTDRELRTN NSQLTAGQRL YQQLGLTGAR GEAEAGYPLV INHALPHYLT
210 220 230 240 250
LLDQGLDPEL ALLDTLLLLM AINGDTNVAS RGGEGGLRWL QREAQTLLQK
260 270 280 290
GGIRTPADLD YLRQFDRECI ERNLSPGGSA DLLILTWFLA QI
Length:292
Mass (Da):31,648
Last modified:February 10, 2009 - v1
Checksum:i722C06F65AEEFDB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928163 Genomic DNA. Translation: CAR11920.1.
RefSeqiWP_000062464.1. NC_011751.1.
YP_002411466.1. NC_011751.1.

Genome annotation databases

EnsemblBacteriaiCAR11920; CAR11920; ECUMN_0706.
GeneIDi7155973.
KEGGieum:ECUMN_0706.
PATRICi18440641. VBIEscCol32010_0904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928163 Genomic DNA. Translation: CAR11920.1.
RefSeqiWP_000062464.1. NC_011751.1.
YP_002411466.1. NC_011751.1.

3D structure databases

ProteinModelPortaliB7N9L9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR11920; CAR11920; ECUMN_0706.
GeneIDi7155973.
KEGGieum:ECUMN_0706.
PATRICi18440641. VBIEscCol32010_0904.

Phylogenomic databases

HOGENOMiHOG000258582.
KOiK05966.
OMAiIHRGGIK.
OrthoDBiEOG6WHNRS.

Family and domain databases

HAMAPiMF_00397. CitG.
InterProiIPR002736. CitG.
IPR017551. TriPribosyl-deP-CoA_syn_CitG.
[Graphical view]
PfamiPF01874. CitG. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03125. citrate_citG. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UMN026 / ExPEC.

Entry informationi

Entry nameiCITG_ECOLU
AccessioniPrimary (citable) accession number: B7N9L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: December 9, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.