Reviewed,
UniProtKB/Swiss-Prot B7N4K1 (ABDH_ECOLU)
Last modified
February 9, 2010.
Version 9.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Gamma-aminobutyraldehyde dehydrogenase EC=1.2.1.19 Alternative name(s): 1-pyrroline dehydrogenase 4-aminobutanal dehydrogenase Short name=ABALDH | ||||
| Gene names |
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| Organism | Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 585056 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 474 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4-aminobutanoate (GABA) By similarity. HAMAP MF_01275 |
| Catalytic activity | 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH. HAMAP MF_01275 |
| Pathway | Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal: step 1/1. HAMAP MF_01275 |
| Subunit structure | Homotetramer By similarity. HAMAP MF_01275 |
| Miscellaneous | 4-aminobutanal is also called gamma-aminobutyraldehyde. HAMAP MF_01275 |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW putrescine catabolic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | NAD or NADH binding Inferred from electronic annotation. Source: HAMAP aminobutyraldehyde dehydrogenase activityInferred from electronic annotation. Source: EC oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptorInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 474 | 474 | Gamma-aminobutyraldehyde dehydrogenase HAMAP MF_01275 | PRO_1000140272 | |||||
Regions | |||||||||
| Nucleotide binding | 172 – 175 | 4 | NAD By similarity | ||||||
| Nucleotide binding | 225 – 231 | 7 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 246 | 1 | By similarity | ||||||
| Active site | 280 | 1 | Nucleophile By similarity | ||||||
| Binding site | 146 | 1 | NAD; via carbonyl oxygen By similarity | ||||||
| Binding site | 209 | 1 | NAD By similarity | ||||||
Sequences
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References
| [1] | "Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths." Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P., Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H., Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E. Denamur E.PLoS Genet. 5:E1000344-E1000344(2009) [PubMed: 19165319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU928163 Genomic DNA. Translation: CAR12894.1. |
| RefSeq | YP_002412431.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 7158620. |
| GenomeReviews | Gene locus ECUMN_1692 in contig CU928163_GR. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG752218. |
| OMA | GYYFQPT. |
Family and domain databases | |
| HAMAP | MF_01275. Aldedh_YdcW. [Tree] |
| InterPro | IPR017749. 1-pyrroline_dehydrogenase. IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03374. ABALDH. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ABDH_ECOLU | ||||||||
| Accession | Primary (citable) accession number: B7N4K1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


