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B7N2U2 (KHSE_ECO81) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:ECED1_0002
OrganismEscherichia coli O81 (strain ED1a) [Complete proteome] [HAMAP]
Taxonomic identifier585397 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP-Rule MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00384

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

homoserine kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Homoserine kinase HAMAP-Rule MF_00384
PRO_1000134251

Regions

Nucleotide binding91 – 10111ATP Potential

Sequences

Sequence LengthMass (Da)Tools
B7N2U2 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 144563D42DAF6D18

FASTA31033,626
        10         20         30         40         50         60 
MVKVYAPASS ANMSVGFDVL GAAVTPVDGA LLGDVVTVEA AETFSLNNLG RFADKLPSEP 

        70         80         90        100        110        120 
RENIVYQCWE RFCQELGKQI PVAMTLEKNM PIGSGLGSSA CSVVAALMAM NEHCGKLLND 

       130        140        150        160        170        180 
TRLLALMGEL EGRISGSIHY DNVAPCFLGG MQLMIEENDI ISQQVPGFDE WLWVLAYPGI 

       190        200        210        220        230        240 
KVSTAEARAI LPAQYRRQDC IAHGRHLAGF IHACYSRQPE LAAKLMKDVI AEPYRERLLP 

       250        260        270        280        290        300 
GFRQARQAVA EIGAVASGIS GSGPTLFALC DKPDTAQRVA DWLGKNYLQN QEGFVHICRL 

       310 
DTAGARVLEN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU928162 Genomic DNA. Translation: CAR06226.1.
RefSeqYP_002396092.1. NC_011745.1.

3D structure databases

ProteinModelPortalB7N2U2.
SMRB7N2U2. Positions 2-308.
ModBaseSearch...

Protein-protein interaction databases

STRING585397.ECED1_0002.

Proteomic databases

PRIDEB7N2U2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR06226; CAR06226; ECED1_0002.
GeneID7141551.
KEGGecq:ECED1_0002.
PATRIC38483917. VBIEscCol8292_0002.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
HOGENOMHOG000247198.
KOK00872.
OMAGFVHICK.
ProtClustDBPRK01212.

Enzyme and pathway databases

BioCycECOL585397:GJCU-2-MONOMER.
UniPathwayUPA00050; UER00064.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00384. Homoser_kinase.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. thrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKHSE_ECO81
AccessionPrimary (citable) accession number: B7N2U2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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